Subclinical hyperthyroidism and dementia: the Sao Paulo Ageing & Health Study (SPAH)
Subclinical hyperthyroidism and dementia: the Sao Paulo Ageing & Health Study (SPAH)
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DOI：
10.1186/1471-2458-10-298
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发表时间：
2010-06-01
影响因子：
4.5
通讯作者：
Scazufca, Marcia
中科院分区：
文献类型：
--
作者：
Bensenor, Isabela M.;Lotufo, Paulo A.;Scazufca, Marcia
背景：多项流行病学研究表明甲状腺功能与认知能力下降之间可能存在关联。我们的目的是评估老年人群体样本中亚临床甲状腺功能亢进症与痴呆的关联方法：一项横断面研究 - 圣保罗老龄化与健康研究 (SPAH) - 在 65 岁以上低收入老年人群体样本中评估亚临床甲状腺疾病是否存在作为痴呆的危险因素。使用促甲状腺激素和游离甲状腺素以及常规使用甲状腺激素或抗甲状腺药物来评估甲状腺功能。 “10/66 痴呆研究小组”使用统一的一阶段痴呆诊断程序对痴呆病例进行评估，包括阿尔茨海默病和血管性痴呆。使用逻辑回归模型来检验亚临床甲状腺功能亢进症与痴呆之间可能存在的关联。结果与讨论：痴呆症和亚临床甲状腺功能亢进症的患病率分别为4.4%和3.0%。年龄调整后，我们发现亚临床甲状腺功能亢进症与任何类型的痴呆和血管性痴呆之间存在关联（优势比分别为 4.1，95% 置信区间 [95% CI] 1.3-13.1，和 5.3 95% CI，1.1-26.4）。按性别分析数据，我们发现仅男性亚临床甲状腺功能亢进症与痴呆和阿尔茨海默氏病存在关联（OR，8.0；95% CI，1.5-43.4；OR，12.4；95% CI，1.2-128.4；分别）。样本中没有患有亚临床甲状腺功能减退症的女性出现阿尔茨海默氏病。结论：结果表明，亚临床甲状腺功能亢进症患者与痴呆症之间存在一致的关联。
Background: Several epidemiologic studies have shown a possible association between thyroid function and cognitive decline. Our aim was to evaluate the association of subclinical hyperthyroidism and dementia in a population sample of older peopleMethods: A cross-sectional study - Sao Paulo Ageing & Health Study (SPAH) - in a population sample of low-income elderly people >= 65 years-old to evaluate presence of subclinical thyroid disease as a risk factor for dementia. Thyroid function was assessed using thyrotropic hormone and free-thyroxine as well as routine use of thyroid hormones or antithyroid medications. Cases of dementia were assessed using a harmonized one-phase dementia diagnostic procedure by the "10/66 Dementia Research Group" including Alzheimer's disease and vascular dementia. Logistic regression models were used to test a possible association between subclinical hyperthyroidism and dementia.Results and discussion: Prevalence of dementia and of subclinical hyperthyroidism were respectively of 4.4% and 3.0%. After age adjustment, we found an association of subclinical hyperthyroidism and any type of dementia and vascular dementia (Odds Ratio, 4.1, 95% Confidence Interval [95% CI] 1.3-13.1, and 5.3 95% CI, 1.1-26.4; respectively). Analyzing data by gender, we found an association of subclinical hyperthyroidism with dementia and Alzheimer's disease only for men (OR, 8.0; 95% CI, 1.5-43.4; OR, 12.4; 95% CI, 1.2-128.4; respectively). No women with subclinical hypothyroidism presented Alzheimer's disease in the sample.Conclusion: The results suggest a consistent association among people with subclinical hyperthyroidism and dementia.