Reflectance Confocal Microscopy-State-of-Art and Research Overview
Reflectance Confocal Microscopy-State-of-Art and Research Overview
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DOI：
10.1016/j.sder.2009.06.004
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发表时间：
2009-09-01
影响因子：
--
通讯作者：
Gerger, Armin
中科院分区：
文献类型：
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作者：
Hofmann-Wellenhof, Rainer;Wurm, Elisabeth M. T.;Gerger, Armin
反射共聚焦显微镜（RCM）使人体皮肤在体内成像的准组织学分辨率。黑白白色RCM图像显示皮肤的水平部分，最大深度为350 μ m。迄今为止，已经描述了大量皮肤状况的RCM特征。然而，研究RCM的研究团体的主要焦点在于描述和诊断黑色素细胞皮肤病变。考虑到所有的RCM研究处理黑色素细胞皮肤病变的诊断准确性，敏感性和特异性约为90%和86%，可以发现，提高诊断准确性，改善皮肤镜组织学相关性的评估，在体内活检侧选择，手术边缘评估，并在皮肤病保守治疗的反应控制是这种新的成像方法的一些主要优势。此外，RCM具有远程皮肤病学应用和自动图像分析的固有潜力。本文介绍了不同的皮肤病变的形态学特征和“正常皮肤”的特点，总结了RCM的诊断进展，比较了诊断适用性的研究，并讨论了这一令人兴奋的新成像技术的进一步研究目标。Semin Cutan Med Surg 28：172-179（C）2009 Elsevier Inc. All rights reserved.
Reflectance confocal microscopy (RCM) enables in vivo imaging of human skin at a quasi histologic resolution. The black-and-white RCM images show horizontal sections of the skin, at a maximum depth of 350 mu m. To date, the RCM features of a significant number of skin conditions have been described. The main focus of the research community investigating RCM, however, lies on describing and diagnosing melanocytic skin lesions. Taking into account all RCM studies dealing with diagnostic accuracy in melanocytic skin lesions, sensitivity and specificity of approximately 90% and 86% could be found. Improvement of diagnostic accuracy, improved assessment of dermoscopic-histologic correlation, in vivo biopsy side selection, surgical margin assessment, and response control of conservative therapies in skin diseases are some of the major advantages of this novel imaging method. Additionally, RCM holds inherent potential for teledermatologic application and automated image analyzing. This article describes morphologic features of diverse skin lesions and features of "normal skin," summarizes diagnostic advances of RCM, compares studies dealing with diagnostic applicability, and discusses further research goals of this exciting new imaging technique. Semin Cutan Med Surg 28:172-179 (C) 2009 Elsevier Inc. All rights reserved.