The genetics, if any, of infantile autism and childhood schizophrenia
The genetics, if any, of infantile autism and childhood schizophrenia
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婴儿自闭症和儿童精神分裂症的遗传学（如果有的话）
DOI：
10.1007/bf01543463
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
I. Gottesman
中科院分区：
文献类型：
--
作者：
D. Hanson;I. Gottesman
一个关键的检查数据，并对遗传因素在早期婴儿自闭症和儿童精神分裂症。这两种疾病的极端罕见性使分析变得困难。没有强有力的证据表明遗传学与5岁以前开始的儿童精神病的发展有关。家庭系谱数据不支持心因性传播，因为早发病例的兄弟姐妹很少受到影响。更有可能是生物性而非遗传性病因。遗传因素与接近青春期开始的精神病的发展有关，这些因素似乎与成人精神分裂症的因素重叠。建议重新评估成人型精神分裂症的最低发病年龄。
A critical examination of the data for and against genetic factors in early infantile autism and childhood schizophrenia is presented. The extreme rareness of both disorders made analysis difficult. No strong evidence exists implicating genetics in the development of childhood psychoses that begin before the age of 5. Family pedigree data fail to support psychogenic transmission because very few siblings of early onset cases are affected. Biological but not genetic etiological agents are more likely. Genetic factors are implicated in the development of psychoses that begin near pubescence and such factors appear to overlap with those for adult schizophrenia. Reevaluation of the minimum age of onset for adult-type schizophrenia is suggested.