A Preliminary Study of the Effects of a Single Session of Swedish Massage on Hypothalamic-Pituitary-Adrenal and Immune Function in Normal Individuals
A Preliminary Study of the Effects of a Single Session of Swedish Massage on Hypothalamic-Pituitary-Adrenal and Immune Function in Normal Individuals
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DOI：
10.1089/acm.2009.0634
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发表时间：
2010-10-01
影响因子：
2.6
通讯作者：
Bresee, Catherine
中科院分区：
文献类型：
--
作者：
Rapaport, Mark Hyman;Schettler, Pamela;Bresee, Catherine
目标：按摩疗法在美国是一个价值数十亿美元的产业，8.7% 的成年人在过去一年内至少接受过一次按摩；然而，对于健康个体单次按摩的生理影响知之甚少。本研究的目的是确定单次瑞典式按摩对神经内分泌和免疫功能的影响。据推测，瑞典式按摩疗法会增加催产素 (OT) 水平，从而导致下丘脑-垂体-肾上腺 (HPA) 活性降低并增强免疫功能。 设计：该研究设计是对瑞典式按摩疗法与轻触控制条件进行头对头、单次比较。进行系列测量以确定 OT、精氨酸加压素 (AVP)、肾上腺皮质激素 (ACTH)、皮质醇 (CORT)、循环表型淋巴细胞标记物和有丝分裂原刺激的细胞因子产生。 背景：本研究在学术医疗中心的门诊研究单位进行。受试者：18-45 岁的医学和精神健康成年人参与了本研究研究。干预：测试的干预措施是 45 分钟的瑞典式按摩疗法与轻触控制条件，使用高度具体和相同的方案。结果测量：计算瑞典式按摩疗法与轻触之间关于干预前后 OT、AVP、ACTH、CORT、淋巴细胞标志物和细胞因子水平变化的标准化平均差异。结果：与轻触相比，瑞典式按摩疗法导致 AVP 的效应值大幅下降，CORT 的效应值略有下降，但这些发现不是由 OT 介导的。按摩增加了循环淋巴细胞、CD 25+ 淋巴细胞、CD 56+ 淋巴细胞、CD4+ 淋巴细胞和 CD8+ 淋巴细胞的数量（效应值从 0.14 到 0.43）。与轻触相比，接受瑞典式按摩疗法的受试者中促细胞分裂原刺激的白细胞介素 (IL)-1β、IL-2、IL-4、IL-5、IL-6、IL-10、IL-13 和 IFN-γ 水平降低（效果大小从 -0.22 到 -0.63）。相对于基线测量，瑞典式按摩疗法降低了 IL-4、IL-5、IL-10 和 IL-13 水平。结论：初步数据表明，单次瑞典式按摩疗法可产生可测量的生物效应。如果重复的话，这些发现可能对治疗炎症和自身免疫性疾病有影响。
Objectives: Massage therapy is a multi-billion dollar industry in the United States with 8.7% of adults receiving at least one massage within the last year; yet, little is known about the physiologic effects of a single session of massage in healthy individuals. The purpose of this study was to determine effects of a single session of Swedish massage on neuroendocrine and immune function. It was hypothesized that Swedish Massage Therapy would increase oxytocin (OT) levels, which would lead to a decrease in hypothalamic-pituitary-adrenal (HPA) activity and enhanced immune function.Design: The study design was a head-to-head, single-session comparison of Swedish Massage Therapy with a light touch control condition. Serial measurements were performed to determine OT, arginine-vasopressin (AVP), adrenal corticotropin hormone (ACTH), cortisol (CORT), circulating phenotypic lymphocytes markers, and mitogen-stimulated cytokine production.Setting: This research was conducted in an outpatient research unit in an academic medical center.Subjects: Medically and psychiatrically healthy adults, 18-45 years old, participated in this study.Intervention: The intervention tested was 45 minutes of Swedish Massage Therapy versus a light touch control condition, using highly specified and identical protocols.Outcome measures: The standardized mean difference was calculated between Swedish Massage Therapy versus light touch on pre- to postintervention change in levels of OT, AVP, ACTH, CORT, lymphocyte markers, and cytokine levels.Results: Compared to light touch, Swedish Massage Therapy caused a large effect size decrease in AVP, and a small effect size decrease in CORT, but these findings were not mediated by OT. Massage increased the number of circulating lymphocytes, CD 25+ lymphocytes, CD 56+ lymphocytes, CD4+lymphocytes, and CD8+lymphocytes (effect sizes from 0.14 to 0.43). Mitogen-stimulated levels of interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, and IFN-gamma decreased for subjects receiving Swedish Massage Therapy versus light touch (effect sizes from -0.22 to -0.63). Swedish Massage Therapy decreased IL-4, IL-5, IL-10, and IL-13 levels relative to baseline measures.Conclusions: Preliminary data suggest that a single session of Swedish Massage Therapy produces measurable biologic effects. If replicated, these findings may have implications for managing inflammatory and autoimmune conditions.