Association of dehydroepiandrosterone sulfate, body composition, and physical fitness in independent community-dwelling older men and women
Association of dehydroepiandrosterone sulfate, body composition, and physical fitness in independent community-dwelling older men and women
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DOI：
10.1111/j.1532-5415.1998.tb01036.x
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发表时间：
1998-03-01
影响因子：
6.3
通讯作者：
Mattson, DE
中科院分区：
文献类型：
--
作者：
Abbasi, A;Duthie, EH;Mattson, DE
目的：确定 60 至 80 岁独立社区居住男性和女性的硫酸脱氢表雄酮 (DHEAS)、身体成分和身体健康之间的关系。设计：横断面分析。参与者：居住在威斯康星州东南部城市和郊区社区的 60 岁及以上的独立男性和女性。测量：病史、体格检查、体力活动水平和人体测量对每个受试者进行了测量。使用双能 X 射线吸收法测量总脂肪质量 (TAM) 和去脂体重。使用放射免疫测定法测量硫酸脱氢表雄酮、胰岛素样生长因子-1 (IGF-1)、总睾酮 (TT) 和游离睾酮 (FT)。使用运动压力测试将身体健康测量为 VO(2)max。使用标准测定法分析血液中的脂质。结果：在男性中，DHEAS 与年龄 (r = -.32)、TAM (r = -.27)、脂肪百分比 (r = -.30)、HDL 胆固醇 (r = .34)、TT (r = .30)、VO(2)max (r = .23) 和瘦体重百分比 (% LBM) (r = .33) 显着相关。在女性中，DHEAS 与除体重指数 (BMI) 之外的任何检查变量均没有显着相关性 (r = .23)。在男性中，排除年龄后，DHEAS 与 HDL、脂肪百分比、TAM、LBM 百分比和 TT 显着相关。对男性的多变量分析显示，高密度脂蛋白胆固醇 (HDL) 是血清 DHEAS 水平的最强预测因子，其次是 % LBM、BMI 和年龄。血清 DHEAS 水平最高四分位数的男性与最低四分位数的男性在年龄、IT、FT、脂肪百分比、TAM、LBM 百分比、HDL 和低密度脂蛋白 (LDL) 胆固醇水平方面存在差异。两组女性中没有发现这种差异。结论：在这组独立社区居住的老年男性中，发现几个因素与血清 DHEAS 浓度相关，而在老年女性组中，除了 BMI 之外，没有发现任何此类关联。与血清 DHEAS 水平最低四分位的男性相比，血清 DHEAS 水平最高四分位的男性更年轻、更瘦、更健康，TT 和 FT 水平更高，并且血脂状况良好。血清 DHEAS 水平最高和最低四分位数的女性之间没有发现这种差异。
OBJECTIVES: To determine the association of dehydroepiandrosterone sulfate (DHEAS), body composition, and physical fitness in independent community-dwelling men and women aged 60 to 80 years.DESIGN: Cross sectional analysis.PARTICIPANTS: Independent men and women, 60 years of age and older, living in urban and suburban communities of Southeastern Wisconsin.MEASUREMENTS: History, physical examination, physical activity level, and anthropometrics were measured for every subject. Total adipose mass (TAM) and lean body mass were measured using dual energy X-ray absorptiometry. Dehydroepiandrosterone sulfate, insulin-like growth factor-1 (IGF-1), total testosterone (TT), and free testosterone (FT) were measured using radioimmunoassay. Physical fitness was measured as VO(2)max using exercise stress tests. Blood for lipids was analyzed using standard assays.RESULTS: In men, the DHEAS was significantly correlated to age (r = -.32), TAM (r = -.27), percent fat (r = -.30), HDL cholesterol (r = .34), TT (r = .30), VO(2)max (r = .23), and percent lean body mass (% LBM) (r = .33). In women, the DHEAS was not significantly correlated to any of the variables examined except body mass index (BMI) (r = .23). In men, after partialling out age, DHEAS was significantly correlated to HDL, % fat, TAM, % LBM, and TT. Multivariate analysis for men revealed that high density lipoprotein cholesterol (HDL) was the strongest predictor of serum DHEAS level, followed by % LBM, BMI, and age. The men in the highest quartile of serum DHEAS levels were different from those in the lowest quartile in terms of age, IT, FT, % fat, TAM, % LBM, HDL, and low density lipoprotein (LDL) cholesterol level. No such differences were found in the two groups of women.CONCLUSION: In this group of independent community-dwelling older men, several factors were found to be associated with the serum DHEAS concentration, whereas in a group of older women, no such associations were identified with the exception of BMI. Men in the highest quartile of serum DHEAS level, compared with those with a serum DHEAS level in the lowest quartile, were younger, leaner, more fit, had higher TT and FT levels, and had a favorable lipid profile. No such differences were identified between the women in the highest and the lowest quartiles of serum DHEAS level.