After the duplication: Gene loss and adaptation in Saccharomyces genomes
After the duplication: Gene loss and adaptation in Saccharomyces genomes
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DOI：
10.1534/genetics.105.048900
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发表时间：
2006-02-01
期刊：
影响因子：
3.3
通讯作者：
Johnston, M
中科院分区：
文献类型：
--
作者：
Cliften, PF;Fulton, RS;Johnston, M
与复制事件发生前分化的相关物种的基因组相比，酿酒酵母基因组的古老复制和随后的大量复制基因丢失是显而易见的。为了进一步了解复制事件对进化的影响，我们将酿酒酵母基因组与其他酵母菌基因组进行了比较。研究结果表明，castellii在与酿酒葡萄分化之前就已经发生了全基因组复制。除了更准确地确定复制事件的年代外，这一发现还使其能够研究复制对两个不同谱系的影响。对基因组重复区域的分析表明，大部分重复基因（约85%）在物种形成之前就丢失了。只有少量的同源基因丢失（4-6%）发生在物种形成之后。另一方面，castellii似乎失去了几百个基因，这些基因没有作为重复的相似物保留下来。这些损失可能与基因组重排有关，将16条染色体的数量减少到9条。除了castellii之外，其他的Saccharomyces sensu lato物种也可能在复制后分化为酿酒酵母（S. cerevisiae）。对这些物种的彻底分析可能会揭示全基因组复制的其他重要结果。
The ancient duplication of the Saccharomyces cerevisiae genome and subsequent massive loss of duplicated genes is apparent Mien it is compared to the genomes of related species that diverged before the duplication event. To learn more about the evolutionary effects of the duplication event, we compared the S. cerevisiae genome to other Saccharomyces genomes. We demonstrate that the whole genome duplication occurred before S. castellii diverged front S. cerevisiae. hi addition to more accurately dating the duplication event, this finding allowed Its to study the effects of the duplication on two separate lineages. Analyses of the duplication regions of the genomes indicate that most of the duplicated genes (similar to 85%) were lost before the speciatiori. Only a small amount of paralogous gene loss (4-6%) occurred after speciatiori. On the other hand, S. castellii appears to have lost several hundred genes that were not retained as duplicated paralogs. These losses could be related to genomic rearrangements that reduced the number of chromosomes front 16 to 9. In addition to S. castellii, other Saccharomyces sensu lato species likely diverged front S. cerevisiae after the duplication. A thorough analysis of these species will likely reveal other important outcomes of the whole genome duplication.