Challenges to achieving and maintaining viral suppression among children living with HIV
Challenges to achieving and maintaining viral suppression among children living with HIV
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DOI：
10.1097/qad.0000000000002454
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发表时间：
2020-04-01
期刊：
影响因子：
3.8
通讯作者：
Bitnun, Ari
中科院分区：
文献类型：
--
作者：
Kakkar, Fatima;Lee, Terry;Bitnun, Ari
目的：本研究的目的是确定加拿大艾滋病毒感染儿童在开始联合抗逆转录病毒治疗（cART）后病毒抑制的时间和持久性。设计图：前瞻性、多中心加拿大队列研究（早期儿科启动加拿大儿童治愈队列），使用前瞻性和回顾性收集的数据。研究方法：Kaplan-Meir生存率估计值和考克斯回归用于确定病毒抑制的时间和风险因素，定义为连续两次检测不到的病毒载量（
Objectives: The objective of this study was to determine the time to, and durability of, viral suppression, among Canadian children living with HIV after initiation of combination antiretroviral therapy (cART). Design: Prospective, multicenter Canadian cohort study (Early Pediatric Initiation Canada Child Cure Cohort), using both prospective and retrospectively collected data. Methods: Kaplan-Meir survival estimates with Cox regression were used to determine the time to and risk factors for viral suppression, defined as two consecutive undetectable viral loads (