Autoantibodies to DNA mismatch repair enzymes in polymyositis/dermatomyositis and other autoimmune diseases: a possible marker of favorable prognosis
Autoantibodies to DNA mismatch repair enzymes in polymyositis/dermatomyositis and other autoimmune diseases: a possible marker of favorable prognosis
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多发性肌炎/皮肌炎和其他自身免疫性疾病中 DNA 错配修复酶的自身抗体：良好预后的可能标志
DOI：
10.1002/art.38866
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发表时间：
2014
影响因子：
13.3
通讯作者：
Akiyama M
中科院分区：
文献类型：
--
作者：
Muro Y;Nakashima R;Hosono Y;Sugiura K;Mimori T;Akiyama M
目的肌炎特异性自身抗体（MSA）是识别特发性炎症性肌病（IIM）患者临床亚型的有用工具。关于 IIM 患者体内某些 DNA 错配修复酶 (MMRE) 抗体的报道很少。本研究旨在确定 IIM 和其他系统性自身免疫性疾病患者中 7 种类型 MMRE（MLH1、MLH3、MSH2、MSH3、MSH6、PMS1 和 PMS2）抗体的频率和临床关联。方法收集了 239 名日本 IIM 患者（147 名成人皮肌炎，13 名青少年皮肌炎）的临床数据和血清样本。皮肌炎，57 例多发性肌炎，22 例肌炎重叠综合征）。一百名患有其他疾病的患者，包括 40 名患有系统性红斑狼疮 (SLE) 的患者，作为疾病对照进行了评估。通过免疫沉淀、酶联免疫吸附测定和免疫沉淀/蛋白质印迹法检查血清中抗 MMRE 抗体的存在。结果在 15 名 IIM 患者和 3 名 SLE 患者中发现了抗 MMRE 抗体。它们仅限于 MLH1、PMS1、MSH2 和 PMS2，并且在某些患者中同时出现不止一种这些抗体呈阳性。 9 名具有抗 MMRE 的 IIM 患者还具有其他 MSA 及其相关的临床特征。所有患有抗 MMRE 的患者在本分析时仍然活着。结论抗 MMRE 抗体通常与其他 MSAs 共存，可能是 IIM 良好预后的血清学标志物。
ObjectiveMyositis‐specific autoantibodies (MSAs) are useful tools for identifying clinical subsets of patients with idiopathic inflammatory myopathies (IIMs). There have been few reports on antibodies to some DNA mismatch repair enzymes (MMREs) in patients with IIMs. This study was undertaken to determine the frequencies and clinical associations of antibodies to 7 types of MMREs (MLH1, MLH3, MSH2, MSH3, MSH6, PMS1, and PMS2) in patients with IIMs and other systemic autoimmune diseases.MethodsClinical data and serum samples were collected from 239 Japanese patients with IIMs (147 with adult dermatomyositis, 13 with juvenile dermatomyositis, 57 with polymyositis, and 22 with myositis overlap syndrome). One hundred patients with other diseases, including 40 with systemic lupus erythematosus (SLE), were assessed as disease controls. The presence of anti‐MMRE antibodies in serum was examined by immunoprecipitation, enzyme‐linked immunosorbent assay, and immunoprecipitation/Western blotting.ResultsAnti‐MMRE antibodies were found in 15 patients with IIMs and 3 patients with SLE. They were restricted to MLH1, PMS1, MSH2, and PMS2, with simultaneous positivity for more than one of these antibodies occurring in some patients. Nine IIM patients with anti‐MMREs also had other MSAs and their associated clinical features. All patients with anti‐MMREs were still living at the time of the present analysis.ConclusionAnti‐MMRE antibodies, which often coexist with other MSAs, may be serologic markers for good prognosis in IIMs.