HUMAN TROPHOBLAST CELL-SURFACE ANTIGENS DEFINED BY MONOCLONAL-ANTIBODIES
HUMAN TROPHOBLAST CELL-SURFACE ANTIGENS DEFINED BY MONOCLONAL-ANTIBODIES
复制标题
DOI：
10.1073/pnas.78.8.5147
复制
发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
HERZENBERG, LA
中科院分区：
文献类型：
--
作者：
LIPINSKI, M;PARKS, DR;HERZENBERG, LA
已制备了一系列抗人绒毛膜癌细胞系BeWo的单克隆抗体。在正常和恶性滋养层细胞上定义了四种抗原，Trop-1、-2、-3和-4。Trop-1和Trop-2似乎在合胞体和细胞滋养层上特异性表达，而Trop-3和Trop-4也在各种肿瘤细胞系、正常淋巴细胞和单核细胞上检测到。抗Trop-1和抗Trop-2抗体可用于检测和分离孕妇血液中循环的胎儿滋养层细胞，以及诊断和治疗绒毛膜癌和其他生殖细胞肿瘤患者。
A series of monoclonal antibodies has been raised against the human choriocarcinoma cell-line, BeWo. Four antigens, Trop-1, -2, -3 and -4, are defined on normal and malignant trophoblast cells. Trop-1 and Trop-2 appear to be specifically expressed on syncytio- and cytotrophoblasts whereas Trop-3 and Trop-4 are also detected on various tumor cell lines, normal lymphocytes and monocytes. Anti-Trop-1 and anti-Trop-2 antibodies might prove useful for detection and isolation of fetal trophoblast cells circulating in pregnant women''s blood and for diagnosis and therapy in patients having choriocarcinomas and other germ-cell neoplasms.