Choreographing endo-lysosomal Ca2+ throughout the life of a phagosome.
Choreographing endo-lysosomal Ca2+ throughout the life of a phagosome.
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DOI：
10.1016/j.bbamcr.2021.119040
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发表时间：
2021-04
期刊：
影响因子：
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通讯作者：
A. Morgan;Lianne C. Davis;A. Galione
中科院分区：
文献类型：
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作者：
A. Morgan;Lianne C. Davis;A. Galione
内溶酶体作为普遍存在的 Ca2+ 储存库及其独特的通道群的出现，导致它们参与越来越多的细胞类型中越来越多的过程。这些酸性 Ca2+ 储存的结构和监管限制将它们与其他较大的 Ca2+ 来源（例如 ER 和跨质膜流入）区分开来。鉴于对操作模式理解的最新进展，我们讨论吞噬作用作为如何将内溶酶体 Ca2+ 信号（通过 TPC 和 TRPML 通道产生）以多种复杂方式整合到生物过程中的模板。吞噬作用说明了不同的内溶酶体 Ca2+ 信号如何驱动过程的不同阶段，以及这些信号如何因疾病或感染而改变。
The emergence of endo-lysosomes as ubiquitous Ca2+stores with their unique cohort of channels has resulted in their being implicated in a growing number of processes in an ever-increasing number of cell types. The architectural and regulatory constraints of these acidic Ca2+stores distinguishes them from other larger Ca2+sources such as the ER and influx across the plasma membrane. In view of recent advances in the understanding of the modes of operation, we discuss phagocytosis as a template for how endo-lysosomal Ca2+signals (generated via TPC and TRPML channels) can be integrated in multiple sophisticated ways into biological processes. Phagocytosis illustrates how different endo-lysosomal Ca2+signals drive different phases of a process, and how these can be altered by disease or infection.