Dietary exposure and human risk assessment of phthalate esters based on total diet study in Cambodia
Dietary exposure and human risk assessment of phthalate esters based on total diet study in Cambodia
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基于柬埔寨总膳食研究的邻苯二甲酸酯膳食暴露和人类风险评估
DOI：
10.1016/j.envres.2016.06.011
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发表时间：
2016-10-01
影响因子：
8.3
通讯作者：
Wong, Ming-Hung
中科院分区：
文献类型：
--
作者：
Cheng, Zhang;Li, Han-Han;Wong, Ming-Hung
邻苯二甲酸酯广泛用于各种消费品中，人类接触这类化合物的情况很普遍。然而，关于人类饮食暴露于邻苯二甲酸盐的研究有限。在这项研究中，为了评估邻苯二甲酸酯的每日摄入量及其可能对健康造成的不利影响，从世界上最贫穷的国家之一柬埔寨的三个地区采集了不同的食物样本。磅湛省、葛莱省和甘达尔省的Sigma邻苯二甲酸酯浓度分别为0.05-2.34(中位数0.88)、0.19-1.65(中位数0.86)和0.24-3.05(中位数0.59)。邻苯二甲酸二乙基己酯(DEHP)和邻苯二甲酸二异丁酯(DIBP)是所有食品中的主要化合物。磅湛、葛莱依和甘达尔地区一般人群的邻苯二甲酸酯估计日摄入量分别为34.3、35.6和35.8mug kg(-1)bw(-1)。磅湛、葛里岛和甘达尔的DEHP、邻苯二甲酸二丁酯(BBP)和邻苯二甲酸二丁酯(DBP)的每日膳食摄入量低于欧洲食品安全局(EFSA)规定的每日容许摄入量(TDI)和美国环境保护局(USEPA)规定的参考剂量(RfD)。在柬埔寨，水稻对DEHP的日摄入量贡献最大，因此可能值得进一步探索。据我们所知，这是第一次调查邻苯二甲酸酯在柬埔寨的发生和每日摄入量的研究。(C)2016 Elsevier Inc.保留所有权利。
Phthalate esters are used in a wide variety of consumer products, and human exposure to this class of compounds is widespread. Nevertheless, studies on dietary exposure of human to phthalates are limited. In this study, to assess the daily intakes of phthalate esters and the possible adverse health impacts, different food samples were collected from three areas of Cambodia, one of the poorest countries in the world. The Sigma phthalate ester concentrations in Kampong Cham, Kratie and Kandal provinces ranged from 0.05 to 2.34 (median 0.88) mu g g(-1), 0.19-1.65 (median 0.86) mu g g(-1) and 0.24-3.05 (median 0.59) mu g g(-1) wet weight (ww), respectively. Di-2-Ethylhexyl phthalate (DEHP) and diisobutyl phthalate (DiBP) were the predominant compounds among all foodstuffs. The estimated daily intake (EDI) of phthalate esters for the general population in Kampong Cham, Kratie and Kandal was 34.3, 35.6 and 35.8 mu g kg(-1) bw d(-1), respectively. The dietary daily intake of DEHP, benzylbutyl phthalate (BBP) and di-n-butyl phthalate (DBP) in Kampong Cham, Kratie and Kandal were below the tolerable daily intakes (TDI) imposed by the European Food Safety Authority (EFSA) and reference doses (RfD) imposed by The United States Environmental Protection Agency (USEPA). Rice contributed the greatest quantity of DEHP to the daily intake in Cambodia so may deserve further exploration. To our knowledge, this is the first study to investigate the occurrence and the daily intakes of phthalate esters in Cambodia. (C) 2016 Elsevier Inc. All rights reserved.