Persistent and chronic diarrhea and malabsorption: Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
Persistent and chronic diarrhea and malabsorption: Working Group Report of the Second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
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DOI：
10.1097/00005176-200406002-00019
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发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Rhoads, JM
中科院分区：
文献类型：
--
作者：
Bhutta, ZA;Ghishan, F;Rhoads, JM
尽管在儿童期牙周炎的理解和管理方面取得了相当大的进展。据估计，它们仍然造成全世界220万儿童死亡（1）。1980年，世界卫生组织计算出每年有超过7亿例儿童腹泻，460万例死亡（2）。最近的审查表明，虽然全球死亡率有所下降。发病率保持不变，>3.2次/儿童年（3）。这些研究结果表明，在发展中国家，需要继续关注儿童急性和慢性腹泻的预防和管理。腹泻疾病形成一个连续性，大多数病例在发病的第一周内消退。然而.一小部分慢性病可能无法解决，并持续2周以上。持续性腹泻（PD）可以定义为在体重没有增加或减轻的儿童中每天排出3次水样便，持续>2周。PD确定了儿童与重大疟疾相关的发病率，占所有疟疾相关死亡的36%至54%（4）。发展中国家的许多婴幼儿可能经常反复发作PD急性腹泻，导致这些儿童营养不良和/或易患PD。关于急性腹泻疾病和PD之间关系的大部分流行病学数据来自> 10至15年前进行的研究。关于这一问题的最新数据很少，特别是来自非艾滋病毒流行地区的数据。然而，慢性肠病和PD已越来越多地被认为是进展、HIV感染和AIDS的表现。
Despite considerable advances in the Understanding C and Management of diarrheal disorders in childhood. they, are still responsible for an estimated 2.2 million childhood deaths worldwide (1). In 1980, the World Health Organization calculated that there were >700 million episodes of diarrhea annually in children 4.6 million deaths (2). More recent reviews indicate that although global mortality has decreased. the incidence remains Unchanged at >3.2 episodes per child-year (3). These findings indicate the Continuing need to focus on the prevention and management of acute and chronic diarrhea in children in developing countries.Diarrheal disorders form a contintuum, the majority of cases resolving within the first week of the illness. However. a smaller proportion of diarrheal illnesses may fail to resolve and persist for >2 weeks. Persistent diarrhea (PD) may be defined as the, passage of 3 watery stools per day for >2 weeks in a child who either fails to gain or loses weight. PD identifies children with a substantial diarrhea-related morbidity and accounts for between 36% and 54% of all diarrhea-related deaths (4). Many infants and toddlers in developing countries may have frequent recurrent episodes of acute diarrhea of PD, resulting in nutritional compromising and/or predisposing these children to PD.The bulk of epidemiological data on the relationship between acute diarrheal disorders and PD are from studies undertaken > 10 to 15 years ago. There is a paucity Of recent data on this subject, especially from non-HIV endemic areas. However, chronic enteropathy and PD have been increasingly recognized as manifestations of advancing, HIV infection and AIDS.