Symptom combinations assessed in traditional Chinese medicine and its predictive role in ACR20 efficacy response in rheumatoid arthritis
Symptom combinations assessed in traditional Chinese medicine and its predictive role in ACR20 efficacy response in rheumatoid arthritis
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DOI：
10.1142/s0192415x08006144
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发表时间：
2008-01-01
影响因子：
5.7
通讯作者：
Tsang, Ian
中科院分区：
文献类型：
--
作者：
He, Yiting;Lu, Aiping;Tsang, Ian
探讨传统中医评价的症状组合在类风湿关节炎（RA）治疗中的预测作用。396例患者随机分为197例西医治疗组和199例中医治疗组。在随机分组前，记录完整的体格检查和18种典型的中医临床表现。ACR反应用于疗效评价。中西医结合治疗组ACR20、50反应均高于中药治疗组。经因子分析可将RA的18种症状聚类为4种症状组合，分别代表中医的关节证、寒证、虚证和热证。中医对弱证型3（中医称虚证型）患者更有效，对症状型2（中医称寒证型）患者更有效。中医辨证论治对类风湿关节炎的疗效有一定影响。
The predictive roles of symptom combination traditionally evaluated in traditional Chinese medicine (TCM) in the treatment of rheumatoid arthritis (RA) were explored. Three hundred and ninety six patients were randomly divided into 197 subjects receiving Western medicine therapy (WM) and 199 subjects receiving TCM therapy (TCM). A complete physical examination and 18 clinical manifestations typically assessed in TCM were recorded before the randomization. The ACR responses were used for efficacy evaluation. ACR20 and 50 responses with WM treatment were higher than in the TCM group. The 18 symptoms in RA could be clustered into 4 symptom combinations with factor analysis, which represent joint symptoms, cold pattern, deficiency pattern and hot pattern in TCM respectively. TCM would be more effective in patients with weak-symptom combination 3 (deficiency pattern in TCM), and WM would be more effective in patients with symptom combination 2 (cold pattern in TCM). Symptom combinations judged with TCM may have influence on the efficacy of therapy in the treatment of RA.