Functional connectivity of frontal cortex in healthy and ADHD children reflected in EEG coherence
Functional connectivity of frontal cortex in healthy and ADHD children reflected in EEG coherence
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DOI：
10.1093/cercor/bhl089
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发表时间：
2007-08-01
期刊：
影响因子：
3.7
通讯作者：
Srinivasan, Ramesh
中科院分区：
文献类型：
--
作者：
Murias, Michael;Swanson, James M.;Srinivasan, Ramesh
异常的功能性脑连接是与认知功能障碍相关的发育性脑障碍的候选因素。我们分析了大量的（10分钟每个主题）的密集阵列脑电图记录与频谱功率和相干方法在注意缺陷多动障碍（ADHD）（n = 42）和对照组（n = 21）10至13岁的儿童。我们发现受试者组之间存在地形上明显的窄带相干性差异：ADHD受试者在较低的α（8 Hz）波段表现出较高的相干性，而在较高的α（10-11 Hz）波段表现出较低的相干性。8-Hz的ADHD海拔和2- 6-Hz的对照组的一致性海拔是独立的刺激呈现。在对视觉刺激的反应中，ADHD组表现出诱发电位功率降低和额叶连贯性升高。只有上α波段对照组相干性升高根据ADHD组用药状态进行区分。研究结果表明，ADHD患者存在静态的连接缺陷状态，而额叶半球内部和之间存在刺激诱导的过度连接状态。
Abnormal functional brain connectivity is a candidate factor in developmental brain disorders associated with cognitive dysfunction. We analyzed a substantial (10 min per subject) record of dense array electroencephalography with spectral power and coherence methods in attention-deficit hyperactivity disorder (ADHD) (n = 42) and control (n = 21) 10- to 13-year-old children. We found topographically distinct narrow band coherence differences between subject groups: ADHD subjects showed elevated coherence in the lower alpha (8 Hz) band and reduced coherence in the upper alpha (10-11 Hz) band. The 8-Hz ADHD elevation and a 2- to 6-Hz control group coherence elevation were independent of stimulus presentation. In response to visual stimulation, the ADHD group exhibited reduced evoked potential power and elevated frontal coherence. Only the upper alpha band control group coherence elevation discriminated according to ADHD group medication status. The findings suggest a static state of deficient connectivity in ADHD and a stimulus-induced state of overconnectivity within and between frontal hemispheres.