Diffusion tensor imaging in spinal cord injury.
Diffusion tensor imaging in spinal cord injury.
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DOI：
10.4103/0971-3026.85372
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Rao SV
中科院分区：
文献类型：
--
作者：
Kamble RB;Venkataramana NK;Naik AL;Rao SV
评估脊髓纤维束成像在脊髓损伤患者与对照组中的可行性，并比较两组之间的各向异性分数（FA）值。对29例患者（18例患者和11例对照）的脊髓进行了扩散张量成像（DTI）。如果脊髓损伤位于背侧或腰侧，则在颈部进行DTI，如果脊髓损伤位于颈侧或背侧，则在圆锥部进行DTI。计算患者和对照组的FA值并进行比较。对照组的平均FA值为0.550±0.09，患者为0.367±0.14;该差异具有统计学意义（P=0.001）。脊髓纤维束成像是一种可行的技术，以评估脊髓损伤的程度，FA，这是减少在脊髓损伤的患者，这表明可能沃勒变性。将来，这项技术可能成为评估干细胞治疗后脊髓损伤患者的有用工具，FA值的改善表明轴突再生。
To assess the feasibility of spinal tractography in patients of spinal cord injury vs a control group and to compare fractional anisotropy (FA) values between the groups. Diffusion tensor imaging (DTI) was performed in the spinal cord of 29 patients (18 patients and 11 controls). DTI was done in the cervical region if the cord injury was at the dorsal or lumbar region and in the conus region if cord injury was in the cervical or dorsal region. FA was calculated for the patients and the controls and the values were compared. The mean FA value was 0.550±0.09 in the control group and 0.367±0.14 in the patients; this difference was statistically significant (P=0.001). Spinal tractography is a feasible technique to assess the extent of spinal cord injury by FA, which is reduced in patients of spinal cord injury, suggesting possible Wallerian degeneration. In future, this technique may become a useful tool for assessing cord injury patients after stem cell therapy, with improvement in FA values indicating axonal regeneration.