Identification of a neuronal cell surface molecule, plexin, in mice
Identification of a neuronal cell surface molecule, plexin, in mice
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DOI：
10.1006/bbrc.1996.1388
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发表时间：
1996-09-13
影响因子：
3.1
通讯作者：
Fujisawa, H
中科院分区：
文献类型：
--
作者：
Kameyama, T;Murakami, Y;Fujisawa, H
我们搜索了最初在非洲爪蟾中发现的细胞粘附蛋白丛蛋白的小鼠同源物，并获得了编码丛蛋白样蛋白的cDNA。我们将这种蛋白质称为小鼠丛蛋白1。小鼠丛蛋白1和非洲爪蟾丛蛋白之间的总体氨基酸同一性为84%。与非洲爪蟾丛蛋白一样，小鼠丛蛋白1蛋白的胞外片段具有三个富含半胱氨酸的结构域，其与c-Met原癌基因蛋白产物（c-Met蛋白）和Met样受体蛋白酪氨酸激酶的富含半胱氨酸的结构域具有显著的同源性。北方印迹分析表明，小鼠丛蛋白1主要在脑中表达。(C)出版社：Academic Press，Inc.
We searched for mouse homologues of the cell adhesion protein plexin which was originally found in Xenopus, and obtained a cDNA encoding a plexin-like protein. We referred to this protein as mouse plexin 1. The overall amino acid identity between mouse plexin 1 and Xenopus plexin was 84%. As in the Xenopus plexin, the extracellular segment of mouse plexin 1 protein possessed three cysteine-rich domains which showed significant homology with the cysteine-rich domain of the c-Met proto-oncogene protein product (c-Met protein) and Met-like receptor protein tyrosine kinases. Northern blot analysis indicated that mouse plexin 1 was predominantly expressed in the brain. (C) 1996 Academic Press, Inc.