Hair Cortisol Analysis: A Promising Biomarker of HPA Activation in Older Adults
Hair Cortisol Analysis: A Promising Biomarker of HPA Activation in Older Adults
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DOI：
10.1093/geront/gnu174
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发表时间：
2015-06-01
期刊：
影响因子：
5.7
通讯作者：
Laudenslager, Mark L.
中科院分区：
文献类型：
--
作者：
Wright, Kathy D.;Hickman, Ronald;Laudenslager, Mark L.
在老年人中，长期的压力是一种潜在的有害且往往未被发现的慢性病风险因素。皮质醇是身体对压力的荷尔蒙反应的指标之一，由下丘脑-垂体-肾上腺(HPA)轴调节，通常在唾液、尿液或血液样本中测量。皮质醇具有昼夜模式，因此收集时间至关重要。头发皮质醇是前几个月HPA轴总回顾活动的替代指标，就像血红蛋白A1c是过去3个月血糖控制的替代指标一样。这篇综述的目的是检验一种新的生物标记物，头发皮质醇，作为与老年人慢性应激相关的长期回溯性皮质醇活动的实用测量。头发皮质醇分析通过更好地将慢性压力描述为慢性病进展的风险因素和减压干预措施的有效性的生物标记物，促进了衰老科学的发展。
Prolonged stress is a potentially harmful and often undetected risk factor for chronic illness in older adults. Cortisol, one indicator of the body's hormonal responses to stress, is regulated by the hypothalamic-pituitary-adrenal (HPA) axis and is commonly measured in saliva, urine, or blood samples. Cortisol possesses a diurnal pattern and thus collection timing is critical. Hair cortisol is a proxy measure to the total retrospective activity of the HPA axis over the preceding months, much like hemoglobin A1c is a proxy measure of glucose control over the past 3 months. The aim of this review is to examine a novel biomarker, hair cortisol, as a practical measure of long-term retrospective cortisol activity associated with chronic stress in older adults. Hair cortisol analysis advances the science of aging by better characterizing chronic stress as a risk factor for chronic illness progression and as a biomarker of the effectiveness of stress reduction interventions.