Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents.
Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents.
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DOI：
10.1097/ypg.0b013e32833511e4
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发表时间：
2010-02
影响因子：
0.9
通讯作者：
Grigorenko EL
中科院分区：
文献类型：
--
作者：
DeYoung CG;Getchell M;Koposov RA;Yrigollen CM;Haeffel GJ;af Klinteberg B;Oreland L;Ruchkin VV;Pakstis AJ;Grigorenko EL
Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in ADHD populations. The present study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. Additionally, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. The current study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. The Val allele of the Val158Met polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. The Val158Met polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population.
