Betaine reduces the irritating effect of sodium lauryl sulfate on human oral mucosa in vivo
Betaine reduces the irritating effect of sodium lauryl sulfate on human oral mucosa in vivo
复制标题
甜菜碱在体内降低十二烷基硫酸钠对人口腔粘膜的刺激作用
DOI：
10.1080/00016350260248292
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发表时间：
2002
影响因子：
2
通讯作者：
E. Söderling
中科院分区：
文献类型：
--
作者：
I. Rantanen;I. Nicander;K. Jutila;S. Ollmar;J. Tenovuo;E. Söderling
我们的目的是评估甜菜碱是否具有保护作用，在人体口腔粘膜在体内暴露于十二烷基硫酸钠（SLS）或椰油酰胺丙基甜菜碱（CAPB）的测量与多频电阻抗谱仪（EI）。在20名志愿者中，两种洗涤剂以2.0%w/v的浓度使用，在蒸馏水中有和没有4.0%w/v甜菜碱，在5名志愿者中，0.5%和1.0%w/v SLS与4.0%w/v甜菜碱组合。在应用测试溶液之前、移除测试溶液之后以及每隔15分钟直至45分钟进行EI测量。0.5%和1% SLS溶液均显示4个指数中的3个显著降低，表明暴露15分钟后的粘膜刺激（P < 0.05），而2% SLS在所有4个指数中均如此（P < 0.001）。甜菜碱对2%或0.5%SLS溶液的洗涤剂诱导的下降没有影响。然而，当与1%SLS溶液组合时，甜菜碱通过消除指数MIX（幅度指数）和IMIX（虚部指数）的降低并降低PIX（相位指数）而显著（P < 0.05）降低粘膜刺激。2%CAPB液在15 min后4项指标均显著降低（P < 0.05），但作用明显弱于2%SLS液（P < 0.05）。甜菜碱不能降低2%CAPB的刺激作用。这些发现可用于开发刺激性较小的口腔保健产品。
Our aim was to evaluate whether betaine has a protective effect during exposure of the human oral mucosa in vivo to sodium lauryl sulfate (SLS) or cocoamidopropylbetaine (CAPB) as measured with a multifrequency electrical impedance spectrometer (EI). Both detergents were used at the concentration of 2.0% w/v with and without 4.0% w/v betaine in distilled water in 20 volunteers, and 0.5% and 1.0% w/v SLS combined with 4.0% w/v betaine in 5 volunteers. EI measurements were taken before application of the test solutions, after their removal, and every 15 min up to 45 min. Both 0.5% and 1% SLS solutions showed a significant reduction in 3 of the 4 indices, indicating mucosal irritation after the 15-min exposure (P < 0.05), whereas 2% SLS did so in all 4 indices (P < 0.001). Betaine had no effect on the detergent-induced decline with either the 2% or the 0.5% SLS solutions. However, when combined with the 1% SLS solution, betaine significantly (P < 0.05) reduced mucosal irritation by abolishing decreases in indices MIX (magnitude index) and IMIX (imaginary part index) and lowering it for PIX (phase index). The 2% CAPB solution showed a significant (P < 0.05) reduction in all 4 indices after the 15-min exposure, but the effect was significantly weaker than that of 2% SLS (P < 0.05). Betaine did not reduce the irritating effect of 2% CAPB. These findings can be used in the development of less irritating products for oral health care.
影响因子：
2.9
作者：
Courtenay, ES;Capp, MW;Record, MT
通讯作者：
Record, MT