ULTRASTRUCTURAL CHARACTERISTICS OF BRAIN AND BLOOD-BRAIN-BARRIER IN EXPERIMENTAL SEIZURES
ULTRASTRUCTURAL CHARACTERISTICS OF BRAIN AND BLOOD-BRAIN-BARRIER IN EXPERIMENTAL SEIZURES
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DOI：
10.1016/0006-8993(77)90539-x
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发表时间：
1977-01-01
期刊：
影响因子：
2.9
通讯作者：
PLUM, F
中科院分区：
文献类型：
--
作者：
PETITO, CK;SCHAEFER, JA;PLUM, F
During experimental seizures, the blood-brain barrier (BBB) is broken; tracer substances such as I131-albumin, Evans blue and horeeradish perioxidase (HRP) geographically locate the barrier breakdown primarily in the diencephalon. Using rats, seizures were induced with electroshocks, and the breakdown of the BBB was demonstrated with Evans blue and HRP. The BBB breakdown was proportional to the number of electroconvulsant shocks (ES) given; the mechanism of increased barrier permeability was primarily by micropinocytosis in the cerebral capillaries, arterioles, and, to a lesser extent, venules; and the stimulus for micropinocytosis and hence BBB breakdown was associated with the abrupt rise in systemic blood pressure and cerebral vasodilatation that accompanies each ES. If the systolic hypertension was abolished via cervical cordotomy, there was little or no breakdown in the BBB.
