Postprandial glucagon-like peptide-1 (GLP-1) response is positively associated with changes in neuronal activity of brain areas implicated in satiety and food intake regulation in humans
Postprandial glucagon-like peptide-1 (GLP-1) response is positively associated with changes in neuronal activity of brain areas implicated in satiety and food intake regulation in humans
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DOI：
10.1016/j.neuroimage.2006.12.035
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发表时间：
2007-04-01
期刊：
影响因子：
5.7
通讯作者：
Krakoff, Jonathan
中科院分区：
文献类型：
--
作者：
Pannacciulli, Nicola;Le, Due Son N. T.;Krakoff, Jonathan
餐后胰高血糖素样肽-1（GLP-1）分泌可作为动物和人类的进餐终止信号。我们通过使用O-15-水正电子发射断层扫描（PET）对饥饿和饱食的神经解剖学相关性的横断面研究进行事后分析，检验了血浆GLP-1浓度的餐后变化与人类大脑活动响应饱食的变化相关的假设。42例受试者（22例男性/201例女性，年龄31 +/- 8岁）涵盖广泛的肥胖（体脂：7-44%）。结果测量包括PET测量的局部脑血流量（rCBF）和GLP-1、葡萄糖、胰岛素和游离脂肪酸（FFA）的血浆浓度的变化，这些变化是由给予饱足量的液体配方餐引起的。餐后血浆GLP-1浓度的峰值增加与左背外侧前额叶皮层的rCBF增加相关（包括左额中回和额下回），以前涉及人类饱腹感的PET研究，以及下丘脑，以前涉及动物和人类研究中食物摄入的调节，在调整性别、年龄、体脂之前和之后，以及血浆葡萄糖、胰岛素和血清FFA浓度的变化。餐后GLP-1反应与先前涉及饱足和食物摄入调节的人脑区域的激活相关。(c)2007年爱思唯尔公司All rights reserved.
Postprandial glucagon-like peptide-1 (GLP-1) secretion can act as a meal termination signal in animals and humans. We tested the hypothesis that the postprandial changes in plasma GLP-1 concentrations are associated with changes in the human brain activity in response to satiety by performing a post-hoc analysis of a cross-sectional study of neuroanatomical correlates of hunger and satiation using O-15-water positron-emission tomography (PET). Forty-two subjects (22M/201F, age 31 +/- 8 years) spanning a wide range of adiposity (body fat: 7-44%) were included in this analysis. Outcome measures included changes in PET-measured regional cerebral blood flow (rCBF) and plasma concentrations of GLP-1, glucose, insulin, and free-fatty acids (FFA), elicited by the administration of a satiating amount of a liquid formula meal. The peak postprandial increases in plasma GLP-1 concentrations were correlated with increases in rCBF in the left dorsolateral prefrontal cortex (including the left middle and inferior frontal gyri), previously implicated in PET studies of human satiation, and the hypothalamus, previously implicated in the regulation of food intake in animal and human studies, both before and after adjustment for sex, age, body fat, and changes in plasma glucose, insulin, and serum FFA concentrations. The postprandial GLP-1 response is associated with activation of areas of the human brain previously implicated in satiation and food intake regulation. (c) 2007 Elsevier Inc. All rights reserved.