CORRELATIONS BETWEEN MECHANICAL-STRESS HISTORY AND TISSUE DIFFERENTIATION IN INITIAL FRACTURE-HEALING
CORRELATIONS BETWEEN MECHANICAL-STRESS HISTORY AND TISSUE DIFFERENTIATION IN INITIAL FRACTURE-HEALING
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DOI：
10.1002/jor.1100060517
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发表时间：
1988-09-01
影响因子：
2.8
通讯作者：
BEAUPRE, GS
中科院分区：
文献类型：
--
作者：
CARTER, DR;BLENMAN, PR;BEAUPRE, GS
本文提出了间歇性施加应力在间充质组织分化中的作用的一般理论，并将其应用于骨折愈合过程。建立了长骨截骨愈合的二维有限元模型，并计算了不同载荷条件下早期骨痂组织的应力分布。这些计算用于制定组织分化的理论预测，与以前的研究人员的生化和形态学观察一致。结果表明，间歇性静水（扩张）应力可能在影响血管重建和组织分化以及决定骨折初始愈合的形态模式方面发挥重要作用。
A general theory for the role of intermittently imposed stresses in the differentiation of mesenchymal tissue is presented and then applied to the process of fracture healing. Two-dimensional finite element models of a healing osteotomy in a long bone were generated and the stress distributions were calculated throughout the early callus tissue under various loading conditions. These calculations were used in formulating theoretical predictions of tissue differentiation that were consistent with the biochemical and morphological observations of previous investigators. The results suggest that intermittent hydrostatic (dilatational) stresses may play an important role in influencing revascularization and tissue differentiation and determining the morphological pattens of initial fracture healing.