Dose correlation for thoracic motion in radiation therapy of breast cancer
Dose correlation for thoracic motion in radiation therapy of breast cancer
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DOI：
10.1118/1.1603744
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发表时间：
2003-09-01
期刊：
影响因子：
3.8
通讯作者：
Ma, CM
中科院分区：
文献类型：
--
作者：
Ding, MS;Li, JS;Ma, CM
本文研究了乳腺癌放疗中胸部运动引起的变形物体的剂量相关性。已经开发了一种分析模型，以基于身体在呼吸期间将成比例地膨胀或压缩的假设来重建患者解剖结构。使用在吸气和呼气阶段获取的CT数据以及可以与测量的胸壁运动相关的呼吸水平来重建呼吸模式期间任何阶段的患者几何形状。建立在呼吸模式的任何阶段处的吸气（或呼气）几何结构中的体素与重建的几何结构中的体素之间的相关性，使得可以在治疗期间累积剂量。该方法已被实施的治疗计划剂量计算通过接口与蒙特卡罗代码。生成用于呼吸模式的不同阶段的患者几何文件，并且从Monte Carlo模拟获得三维剂量数据。最终剂量分布是根据与胸壁运动相关的患者呼吸模式，从不同呼吸阶段的剂量数据重建的。(C)2003年美国医学物理学家协会。
This work investigates the dose correlation for deformed objects due to thoracic motion for radiotherapy treatment of breast cancer. An analytical model has been developed to reconstruct patient anatomy based on the assumption that the body will expand or compress proportionally during respiration. The patient geometry at any phase during a breathing pattern is reconstructed using the CT data taken at the inspiration and expiration phases and the breathing level which can be related to the measured chest wall motion. A correlation between the voxels in the inspiration (or expiration) geometry and the voxels in the reconstructed geometry at any phase of the breathing pattern is established so that the dose can be accumulated during a treatment. The method has been implemented for treatment planning dose calculation by interfacing with a Monte Carlo code. The patient geometry files for different phases of the breathing pattern are generated and the three-dimensional dose data are obtained from the Monte Carlo simulations. The final dose distribution is reconstructed from the dose data at different breathing phases based on patient's breathing pattern associated with chest wall movements. (C) 2003 American Association of Physicists in Medicine.