INFECTIOUS VACCINIA VIRUS RECOMBINANTS THAT EXPRESS HEPATITIS-B VIRUS SURFACE-ANTIGEN
INFECTIOUS VACCINIA VIRUS RECOMBINANTS THAT EXPRESS HEPATITIS-B VIRUS SURFACE-ANTIGEN
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DOI：
10.1038/302490a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
MOSS, B
中科院分区：
文献类型：
--
作者：
SMITH, GL;MACKETT, M;MOSS, B
针对B型肝炎病毒的潜在活疫苗已经生产出来。将B型肝炎病毒表面抗原（HBsAg）的编码序列插入到牛痘病毒基因组中，在牛痘病毒早期启动子的控制下。用这些重组牛痘病毒感染的非洲绿色猴肾细胞合成并分泌HBsAg，接种疫苗的兔子迅速产生HBsAg抗体。
Potential live vaccines against hepatitis B virus have been produced. The coding sequence for hepatitis B virus surface antigen (HBsAg) was inserted into the vaccinia virus genome under control of vaccinia virus early promoters. African green monkey kidney cells infected with these vaccinia virus recombinants synthesize and excrete HBsAg and vaccinated rabbits rapidly produce antibodies to HBsAg.