Bioactive meroditerpenes and indole alkaloids from the soil fungus Neosartorya fischeri (KUFC 6344), and the marine-derived fungi Neosartorya laciniosa (KUFC 7896) and Neosartorya tsunodae (KUFC 9213)
Bioactive meroditerpenes and indole alkaloids from the soil fungus Neosartorya fischeri (KUFC 6344), and the marine-derived fungi Neosartorya laciniosa (KUFC 7896) and Neosartorya tsunodae (KUFC 9213)
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DOI：
10.1016/j.tet.2013.07.078
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发表时间：
2013-10-07
期刊：
影响因子：
2.1
通讯作者：
Kijjoa, Anake
中科院分区：
文献类型：
--
作者：
Eamvijarn, Amnat;Gomes, Nelson M.;Kijjoa, Anake
从土壤真菌Neutraltorya fischeri（KUFC 6344）的培养物中分离出两种新的代谢产物，包括一种新的aszonalenin类似物（1c）和一种新的meroditerpenes（3），以及aszonalenin（1a）、acetylaszonalenin（1B）、13-oxofumitopergin B（2）、aszonapyrone A（4 B）和helvolic acid。而患病的珊瑚源真菌Neaprotorya laciniosa的培养物的乙酸乙酯提取物（KUFC 7896）提供了阿唑那吡喃酮B（4a）、阿唑那吡喃酮A（4 B）、色喹缬氨酸L和3 '-（4-氧代喹唑啉-3-基）螺[1H-吲哚-3，5 '-氧杂环戊烷]-2，2'-二酮，海洋海绵相关真菌松奈氏菌（KUFC 9213）的培养物的乙酸乙酯提取物产生了一种新的chevalone C（5）和helvolic acid的类似物。新化合物的结构经1D、2D NMR和HR-ESIMS确证。通过蛋白质结合染料SRB方法评价化合物1a-c、2、3、4a、4 b和5对MCF-7（乳腺癌）、NCI-H460（非小细胞肺癌）和A375-C5（黑色素瘤）细胞系的体外生长抑制活性。(C)2013爱思唯尔有限公司保留所有权利。
Two new metabolites including a new aszonalenin analogue (1c) and a new meroditerpene (3) were isolated, together with aszonalenin (1a), acetylaszonalenin (1b), 13-oxofumitremorgin B (2), aszonapyrone A (4b) and helvolic acid, from the culture of the soil fungus Neosartorya fischeri (KUFC 6344). While the ethyl acetate extract of the culture of the diseased coral-derived fungus Neosartorya laciniosa (KUFC 7896) furnished aszonapyrone B (4a), aszonapyrone A (4b), tryptoquivaline L and 3'-(4-oxoquinazolin-3-yl) spiro[1H-indole-3,5'-oxolane]-2,2'-dione, the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213) yielded a new analogue of chevalone C (5) and helvolic acid. The structures of the new compounds were established based on 1D and 2D NMR spectral analysis as well as HR-ESIMS. Compounds 1a-c, 2, 3, 4a, 4b and 5 were evaluated for their in vitro growth inhibitory activity on the MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma) cell lines by the protein binding dye SRB method. (C) 2013 Elsevier Ltd. All rights reserved.