Lignin Nanoparticles: Green Synthesis in a γ-Valerolactone/Water Binary Solvent and Application to Enhance Antimicrobial Activity of Essential Oils
Lignin Nanoparticles: Green Synthesis in a γ-Valerolactone/Water Binary Solvent and Application to Enhance Antimicrobial Activity of Essential Oils
复制标题
木质素纳米颗粒：γ-戊内酯/水二元溶剂中的绿色合成及其在增强精油抗菌活性中的应用
DOI：
10.1021/acssuschemeng.9b06716
复制
发表时间：
2020-01-13
影响因子：
8.4
通讯作者：
Gong, Liang
中科院分区：
文献类型：
--
作者：
Chen, Liheng;Shi, Yunfeng;Gong, Liang
木质素纳米颗粒（LNPs）是一种可再生和可生物降解的木质素的特殊聚集体，具有良好的水溶性、生物相容性和环境友好性等优点，是一种理想的砌块材料。为了开发一种有前途的生产LNP的方法，我们开发了一种使用回收的γ-戊内酯（GVL）/水二元溶剂（GWBS）的简单且可持续的合成方法。不同来源的木质素在GWBS中的溶解度可达200 g/L。通过木质素溶液的纳米沉淀（滴加或透析）容易地获得LNP。LNP的产率和尺寸可以在纳米沉淀期间控制。采用滴加纳米沉淀法，LNP的产率最高可达90%，相应的初始浓度可达24 g/L。这种高效的滴加方法可能提供一种用于放大生产LNP的方法。所得的LNP具有约100 μ m的直径。在250 nm和-40 mV的ζ-电位下，也显示出良好的分散性和在水中的稳定性。LNP可以稳定精油并促进其对微生物的生长抑制活性。这些结果表明，我们还开创了一种用全生物质化学品实现增强抗菌剂的新方法。
Lignin nanoparticles (LNPs), as a special aggregate of renewable and biodegradable lignin available in abundant amounts, are a perfect building-block material because of their advantages, including good dispersibility in water, great biocompatibility, and eco-friendly characteristics. To exploit a promising method of producing LNPs, we developed a simple and sustainable synthesis approach using a recycled gamma-valerolactone (GVL)/water binary solvent (GWBS). Up to 200 g/L lignin from several sources could be completely dissolved in GWBS. LNPs were easily obtained through nanoprecipitation (dropping or dialysis) of the lignin solution. The yield and size of LNPs can be controlled during nanoprecipitation. The highest yield of LNP reached 90% via dropping nanoprecipitation, and its relevant initial concentration was up to 24 g/L. This highly efficient dropping method might provide a method for scaled-up production of LNPs. The resultant LNPs, having a diameter of ca. 250 nm and a zeta-potential of -40 mV, also showed good dispersibility and stability in water. LNPs can stabilize essential oils and promote their growth inhibition activity against microbes. These results indicated that we also initiated a new method of achieving enhanced antimicrobials with whole biomass-based chemicals.