Assessing corneal cross-linking with reverberant 3D optical coherence elastography.
Assessing corneal cross-linking with reverberant 3D optical coherence elastography.
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DOI：
10.1117/1.jbo.27.2.026003
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发表时间：
2022-03
影响因子：
3.5
通讯作者：
Parker KJ
中科院分区：
文献类型：
--
作者：
Ge GR;Tavakol B;Usher DB;Adler DC;Rolland JP;Parker KJ
角膜交联（CXL）是用于治疗某些眼部疾病如圆锥角膜的众所周知的程序。然而，表征角膜的生物力学变化，由于这一程序仍在积极的研究。具体地，存在对个体角膜层的高分辨率表征的临床需要。高分辨率弹性成像方法结合自定义光学相干断层扫描系统用于跟踪各个角膜层中的这些生物力学变化。对低剂量和高剂量CXL实验进行治疗前和治疗后分析。最近开发的弹性成像技术，利用反射剪切波场的理论，与光学相干断层扫描作为模态，应用于猪角膜离体评估与角膜CXL相关的弹性变化。在每次实验用三对猪角膜治疗之前和之后评价低剂量和高剂量CXL治疗组。混响三维（3D）光学相干弹性成像（OCE）技术可以识别与低剂量和高剂量CXL治疗相关的弹性增加。低剂量和高剂量治疗之间存在显著的图形差异。此外，该技术能够识别角膜的哪些层可能受到CXL手术的影响，并提供对弹性变化的非线性的洞察。混响3D OCE技术可以识别与CXL手术相关的角膜弹性的深度分辨变化。该方法可用于评估和监测CXL在各种临床环境中的疗效。
Corneal cross-linking (CXL) is a well-known procedure for treating certain eye disorders such as keratoconus. However, characterization of the biomechanical changes in the cornea as a result of this procedure is still under active research. Specifically, there is a clinical need for high-resolution characterization of individual corneal layers. A high-resolution elastography method in conjunction with a custom optical coherence tomography system is used to track these biomechanical changes in individual corneal layers. Pre- and post-treatment analysis for both low-dose and high-dose CXL experiments are performed. A recently developed elastography technique that utilizes the theory of reverberant shear wave fields, with optical coherence tomography as the modality, is applied to pig corneas ex vivo to evaluate elasticity changes associated with corneal CXL. Sets of low-dose and high-dose CXL treatments are evaluated before and after treatments with three pairs of pig corneas per experiment. The reverberant three-dimensional (3D) optical coherence elastography (OCE) technique can identify increases in elasticity associated with both low-dose and high-dose CXL treatments. There is a notable graphical difference between low-dose and high-dose treatments. In addition, the technique is able to identify which layers of the cornea are potentially affected by the CXL procedure and provides insight into the nonlinearity of the elasticity changes. The reverberant 3D OCE technique can identify depth-resolved changes in elasticity of the cornea associated with CXL procedures. This method could be translated to assess and monitor CXL efficacy in various clinical settings.