Phagocytosis of Unopsonized Zymosan by Human Monocyte‐Derived Macrophages: Maturation and Inhibition by Mannan
Phagocytosis of Unopsonized Zymosan by Human Monocyte‐Derived Macrophages: Maturation and Inhibition by Mannan
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人单核细胞源性巨噬细胞对未经调理的酵母聚糖的吞噬作用：甘露聚糖的成熟和抑制
DOI：
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发表时间：
1985
影响因子：
5.5
通讯作者：
S. Silverstein
中科院分区：
文献类型：
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作者：
D. Speert;S. Silverstein
人单核细胞衍生的巨噬细胞在不存在血清调理素的情况下吞噬酵母聚糖。体外培养3天后，细胞摄取酵母聚糖的能力开始增强，并被甘露聚糖完全抑制。我们得出结论，人单核细胞衍生的巨噬细胞主要通过甘露糖受体吞噬未调理的酵母聚糖。
Human monocyte‐derived macrophages phagocytosed zymosan in the absence of serum opsonins. The capacity to ingest zymosan developed after the cells were cultured in vitro for 3 days and was inhibited completely by mannan. We conclude that human monocyte‐derived macrophages phagocytose unopsonized zymosan predominantly via mannose receptors.