Gene-environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolers
Gene-environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolers
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DOI：
10.1002/dev.20152
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发表时间：
2006-07-01
影响因子：
2.2
通讯作者：
van Ijzendoorn, Marinus H.
中科院分区：
文献类型：
--
作者：
Bakermans-Kranenburg, Marian J.;van Ijzendoorn, Marinus H.
先前的研究将儿童的攻击性和其他外化问题与多巴胺D4受体多态性或严厉和不敏感的父母有关。在这项研究中，它是确定是否组合的DRD 4 7-重复多态性和母亲的不敏感性预测显着更多的学龄前儿童的外向行为。结果指出了一个基因-环境相互作用的影响：母亲的不敏感与外化（对立，侵略性）的行为，但只有在DRD 4 7-重复多态性的存在。与没有这些组合风险的儿童相比，暴露于不敏感护理的7-重复等位基因的儿童的外化行为增加了6倍。这些数据表明，儿童对依赖于7重复DRD 4等位基因的存在的不敏感的父母的差异敏感。(c)2006 Wiley Periodicals，Inc. Dev Psychobiol 48：406-409，2006.
Previous studies have related aggression and other externalizing problems in children to either dopamine D4 receptor polymorphisms or harsh and insensitive parenting. In this study it was determined whether the combination of the DRD4 7-repeat polymorphisin and maternal insensitivity predicted significantly more externalizing behavior in preschoolers. The results pointed to a gene-environment interaction effect: maternal insensitivity was associated with externalizing (oppositional, aggressive) behaviors, but only in the presence of the DRD4 7-repeat polymorphism. The increase in externalizing behaviors in children with the 7-repeat allele exposed to insensitive care compared to children without these combined risks was sixfold. The data indicate that children are differentially susceptible to insensitive parenting dependent on the presence of the 7-repeat DRD4 allele. (c) 2006 Wiley Periodicals, Inc. Dev Psychobiol 48: 406-409, 2006.