Cellular and molecular mechanisms of memory: the LTP connection
Cellular and molecular mechanisms of memory: the LTP connection
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DOI：
10.1016/s0959-437x(99)80050-1
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发表时间：
1999-06-01
影响因子：
4
通讯作者：
Mayford, M
中科院分区：
文献类型：
--
作者：
Miller, S;Mayford, M
记忆形成的细胞和分子机制的研究集中在突触可塑性的长期形式的作用，如长时程增强（LTP），遗传，电生理和行为技术的组合已被用来检查的可能性，LTP是在哺乳动物大脑中的记忆存储的细胞机制。尽管确切的答案仍然难以捉摸，但很明显，在许多情况下，改变LTP的操作会改变记忆，而产生记忆的训练方案可以产生LTP，就像突触传递的增强一样。
Studies of the cellular and molecular mechanisms of memory formation have focused on the role of long-lasting forms of synaptic plasticity such as long-term potentiation (LTP), A combination of genetic, electrophysiological and behavioral techniques have been used to examine the possibility that LTP is a cellular mechanism of memory storage in the mammalian brain. Although a definitive answer remains elusive, it is clear that in many cases manipulations that alter LTP alter memory, and training regimens that produce memory can produce LTP like potentiation of synaptic transmission.