Increase in local cerebral blood flow induced by circulating adrenaline: involvement of blood-brain barrier dysfunction.
Increase in local cerebral blood flow induced by circulating adrenaline: involvement of blood-brain barrier dysfunction.
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循环肾上腺素引起的局部脑血流量增加：血脑屏障功能障碍的参与。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
Bo K. Siesjö
中科院分区：
文献类型：
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作者：
Ali Abdul;N. Dahlgren;Barbro B. Johansson;Bo K. Siesjö
本文以~(14)C-安替比林为扩散示踪剂，用放射自显影技术测定了静脉滴注肾上腺素(8微克·kg~(-1)·min~(-1))对瘫痪和人工呼吸大鼠局部脑血流量的影响。在这个剂量下，肾上腺素总是增加局部脑血流量，即使在测量脑血流量时血压接近正常。平均而言，局部脑血流量增加到对照的400%。在9只动物中，6只动物的血流增加是不均匀的，随机分布的区域的流速非常高。静脉注射的实验。在注射肾上腺素前给予伊文思蓝显示，4只动物中有3只出现伊文思蓝外渗区。尽管渗出区通常对应于高流速的区域，但前者的范围要小得多。此外，在没有血脑屏障功能障碍迹象的区域发现了非常高的流速。结论是，CBF的增加至少部分是由于压力介导的肾上腺素穿过血脑屏障，但这种途径可以在没有肉眼可见的蛋白质外渗的情况下发生。
The influence of intravenous infusion of adrenaline (8 micrograms.kg-1.min-1) upon local cerebral blood flow (CBF) in paralyzed and artifically ventilated rats was measured autoradiographically with 14C-iodoantipyrine as the diffusible tracer. At this dose, adrenaline invariably increased local CBF even though blood pressure was close to normal at the time of the CBF measurement. In average, local CBF increased to 400% of control. In 6 of 9 animals the increase in flow was inhomogenous with randomingly distributed areas of very high flow rates. Experiments with i.v. administration of Evans blue prior to infusion of adrenaline showed that areas of Evans blue extravasation appeared in 3 of 4 animals. Although areas of extravasation often corresponded to areas of high flow rates the former were much more circumscribed. Furthermore, very high flow rates were found in areas showing no sign of blood-brain barrier dysfunction. It is concluded that the increase in CBF was at least partly due to a pressure-mediated passage of adrenaline across the blood-brain barrier but that such a passage can occur in the absence of macroscopically visible extravasation of protein.