Enhanced phase-amplitude coupling of human electrocorticography selectively in the posterior cortical region during rapid eye movement sleep
Enhanced phase-amplitude coupling of human electrocorticography selectively in the posterior cortical region during rapid eye movement sleep
复制标题
快速眼动睡眠期间后皮质区域选择性增强人类皮层电图的相幅耦合
DOI：
10.1093/cercor/bhac079
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Ikeda Akio
中科院分区：
文献类型：
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作者：
Togawa Jumpei;Matsumoto Riki;Usami Kiyohide;Matsuhashi Masao;Inouchi Morito;Kobayashi Katsuya;Hitomi Takefumi;Nakae Takuro;Shimotake Akihiro;Yamao Yukihiro;Kikuchi Takayuki;Yoshida Kazumichi;Kunieda Takeharu;Miyamoto Susumu;Takahashi Ryosuke;Ikeda Akio
在觉醒和睡眠过程中，慢波(三角洲波或潜流波)和快波(伽马波)相互作用的时空动力学尚未在人类皮层脑电(ECoG)中阐明。本文应用皮层脑电对11例难治性局灶性癫痫患者进行了相位-幅度耦合(PAC)的检测，它反映了信息处理中神经元的编码。在0.5-0.6 GHz的慢波和伽马活动之间观察到PAC，不仅在轻睡眠和慢波睡眠(SWS)中，甚至在觉醒和快速眼动(REM)睡眠中也观察到PAC。在SWS期间，PAC在大范围内升高，而在REM睡眠中，PAC在颞顶交界处的后部皮质区域比额叶皮质区域更强。即使在清醒状态下，大脑皮质后部的PAC也往往高于额叶皮质。我们的发现表明，大脑皮层后部区域在快速眼动睡眠中起着功能作用，可能有助于维持做梦的体验。
The spatiotemporal dynamics of interaction between slow (delta or infraslow) waves and fast (gamma) activities during wakefulness and sleep are yet to be elucidated in human electrocorticography (ECoG). We evaluated phase-amplitude coupling (PAC), which reflects neuronal coding in information processing, using ECoG in 11 patients with intractable focal epilepsy. PAC was observed between slow waves of 0.5–0.6 Hz and gamma activities, not only during light sleep and slow-wave sleep (SWS) but even during wakefulness and rapid eye movement (REM) sleep. While PAC was high over a large region during SWS, it was stronger in the posterior cortical region around the temporoparietal junction than in the frontal cortical region during REM sleep. PAC tended to be higher in the posterior cortical region than in the frontal cortical region even during wakefulness. Our findings suggest that the posterior cortical region has a functional role in REM sleep and may contribute to the maintenance of the dreaming experience.