Serum CD121a (Interleukin 1 Receptor, Type I): A Potential Novel Inflammatory Marker for Coronary Heart Disease.
Serum CD121a (Interleukin 1 Receptor, Type I): A Potential Novel Inflammatory Marker for Coronary Heart Disease.
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血清 CD121a（白细胞介素 1 受体，I 型）：一种潜在的新型冠心病炎症标志物。
DOI：
10.1371/journal.pone.0131086
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Lu X
中科院分区：
文献类型：
--
作者：
Liu Z;Zhang M;Wu J;Zhou P;Liu Y;Wu Y;Yang Y;Lu X
炎症现在被认为是导致冠心病的原因。这一观点刺激了各种炎症标志物对冠心病预测的评估。本研究旨在探讨四种炎症细胞因子（CD121a、白细胞介素[IL]-1β、IL-8和IL-11）与冠心病的关系。在这里，我们评估了443例冠心病患者和160例无冠心病患者，他们接受了冠状动脉造影。采用流式细胞术评估细胞因子水平，并进行统计学分析，探讨细胞因子水平与冠心病风险之间的关系。冠心病患者的CD121a水平明显升高。在年龄和性别校正模型中，CD121a四分位数增加导致冠心病的比值比分别为1.00、1.47[95%可信区间（CI）： 0.79-2.72]、2.67 （95% CI: 1.47 - 4.84）和4.71 (95% CI: 2.65-8.37)，而在多协变量校正模型中，比值比分别为1.00、1.48 （95% CI: 0.70-3.14）、2.25 （95% CI: 1.10-4.62）和4.39 （95% CI: 2.19-8.79）。一项比较稳定型心绞痛、不稳定型心绞痛和急性心肌梗死（AMI）亚组的研究显示，AMI患者的CD121a水平最高，尽管所有组的IL-1β水平相似。AMI患者IL-8水平升高，冠心病患者IL-11水平高于非冠心病患者。相关分析显示CD121a、IL-8与Gensini评分呈正相关。总之，CD121a水平在冠心病患者中显著升高表明它可能是预测冠心病的一种新的炎症标志物。
Inflammation is now believed to be responsible for coronary heart disease (CHD). This belief has stimulated the evaluation of various inflammatory markers for predicting CHD. This study was designed to investigate the association between four inflammatory cytokines (CD121a, interleukin [IL]-1β, IL-8, and IL-11) and CHD. Here, we evaluated 443 patients with CHD and 160 CHD-free controls who underwent coronary angiography. Cytokines were evaluated using flow cytometry, and statistical analyses were performed to investigate the association between cytokine levels and the risk of CHD. Patients with CHD had significantly higher levels of CD121a. The odds ratios for CHD according to increasing CD121a quartiles were 1.00, 1.47 [95% confidence interval (CI): 0.79–2.72], 2.67 (95% CI: 1.47–4.84), and 4.71 (95% CI: 2.65–8.37) in an age- and sex-adjusted model, compared to 1.00, 1.48 (95% CI: 0.70–3.14), 2.25 (95% CI: 1.10–4.62), and 4.39 (95% CI: 2.19–8.79) in a model that was adjusted for multiple covariates. A comparison of the stable angina, unstable angina, and acute myocardial infarction (AMI) subgroups revealed that patients with AMI had the highest CD121a levels, although IL-1β levels were similar across all groups. IL-8 levels were also increased in AMI patients, and IL-11 levels were higher in CHD patients than in non-CHD patients. Correlation analysis revealed a positive association between CD121a, IL-8, and the Gensini score. Together, the significant increase in CD121a levels among CHD patients suggests that it may be a novel inflammatory marker for predicting CHD.
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影响因子：
3.7
作者：
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通讯作者：
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