Neuropathy of Gastrointestinal Chagas' Disease: Immune Response to Myelin Antigens
Neuropathy of Gastrointestinal Chagas' Disease: Immune Response to Myelin Antigens
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DOI：
10.1159/000179667
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发表时间：
2009-01-01
影响因子：
2.4
通讯作者：
Santos, Leonilda M. B.
中科院分区：
文献类型：
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作者：
Oliveira, Elaine C.;Fujisawa, Marcia M.;Santos, Leonilda M. B.
大多数关于感染克氏锥虫时的自身免疫反应的报道都涉及心肌病形式的恰加斯病，但对胃肠道形式所涉及的组织损伤机制知之甚少，本文对此进行了研究。慢性感染的严重胃肠道形式的恰加斯病患者表现出对周围髓鞘成分的抗体产生和增殖反应增加，例如髓鞘碱性蛋白(MBP)，它与周围髓鞘的P1蛋白部分同源。T淋巴细胞优先识别MBP分子上的一个区域(1-30)，这表明MBP是查格斯病引起的胃肠道损害患者周围神经上潜在的自身免疫反应的靶点。版权所有(C)2008 S.Karger AG，巴塞尔
Most reports of autoimmune response during infection with the parasite Trypanosoma cruzi have dealt with the cardiomyopathic form of Chagas' disease, but little is known about the mechanisms of tissue damage involved in the gastrointestinal form, which was studied here. Chronically infected patients with a severe gastrointestinal form of Chagas' disease present increased antibody production and proliferative responses to peripheral myelin components, such as myelin basic protein (MBP), which is homologous to the P1 protein fraction of peripheral myelin. T lymphocytes preferentially recognize a region on the MBP molecule (1-30), which suggests that the MBP is a potential target on the peripheral nerve for autoimmune reactions in patients with gastrointestinal lesions resulting from Chagas' disease. Copyright (C) 2008 S. Karger AG, Basel