Depression and ionizing radiation.
Depression and ionizing radiation.
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发表时间：
2013
影响因子：
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通讯作者：
K. Loganovsky;Z. L. Vasilenko
中科院分区：
文献类型：
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作者：
K. Loganovsky;Z. L. Vasilenko
这篇论文的目的是分析已发表的数据，这些数据与自己对电离辐射在抑郁症发生中的潜在作用的研究结果相关。抑郁症是原子弹爆炸、核试验和辐射紧急情况造成的最显著和长期的影响之一。切尔诺贝利核电站事故的参与者增加了抑郁症的患病率（对照组为18.0%和13.1%）和自杀率。抑郁症是主要见于结构性脑血管病的一种器质性精神障碍。临床表现以弱性情感性抑郁和弱性情感性抑郁为主。辐射突发事件中抑郁障碍的发生是多因素的，是暴露于复杂的心因性和放射性事故因素、传统危险因素、躯体和神经系统疾病、遗传易感性、易感性等多种因素共同作用的结果。同时，电离辐射暴露也是抑郁症发生的一个因素。这种影响可以是直接的（对中枢神经系统），也可以通过躯体和神经系统异常（多器官功能障碍）以及最近发现的电离辐射对大脑的各种致病机制间接产生。非常有必要进行分析性临床和流行病学研究，对抑郁症进行验证，并以证据为基础确定辐射和非辐射危险因素的作用。
The objective of this at issue paper is the analysis of published data in correlation with the results of own research on the potential role of ionizing radiation in the genesis of depressive disorders. Depression is one of the most significant and long-term effect of the atomic bombings, nuclear testing and radiation emergences. The participants of the accident at the Chornobyl nuclear power plant increased prevalence of depression (18.0% and 13.1% in controls) and suicide rates. Depression is mainly observed in the structure of an organic mental disorder against cerebrovascular disease. The clinical pattern is dominated by asthenoadynamic and asthenoapathetic depression. Depressive disorders in radiation emergencies are multifactorial, that is the result of exposure to the complex psychogenic and radiological accident's factors, impact of traditional risk factors, somatic and neurological diseases, genetic predisposition, predisposition, etc. At the same time, exposure to ionizing radiation is a factor in the genesis of depression. This impact can be direct (to the Central Nervous System), and indirectly through the somatic and neurological abnormalities (multiorgan dysfunction) as well as by a variety of pathogenic mechanisms of ionizing radiation on the brain that have been discovered recently. It is strongly necessary analytical clinical and epidemiological studies with verification of depression and evidence-based establishment of the role of radiation and non-radiation risk factors.