Stimulation of the sympathetic nervous system during sucrose feeding
Stimulation of the sympathetic nervous system during sucrose feeding
复制标题
蔗糖喂养过程中交感神经系统的刺激
DOI：
10.1038/269615a0
复制
发表时间：
1977
期刊：
影响因子：
64.8
通讯作者：
L. Landsberg
中科院分区：
文献类型：
--
作者：
James B. Young;L. Landsberg
大鼠的交感神经系统的活动在禁食2天后显著降低，这种抑制可被喂食逆转。对禁食大鼠尿中儿茶酚胺排泄的研究证实了这些发现，此外还表明，在重新喂食的第二天和第三天，尿中肾上腺素和去甲肾上腺素（NA）排泄实际上超过了基线水平2。由于这些先前禁食动物的饮食摄入量在再喂食期间大于基线，因此出现过度喂食可能与交感神经活动增加相关的可能性，并导致本研究。其他人的工作提供了证据，证明用含蔗糖的饮用溶液补充标准大鼠食物饮食可使大鼠的总热量摄入增加约20%3。因此，大鼠自愿过度喂养的实验设计是基于在实验期间向动物随意获取大鼠食物和水的动物中添加含蔗糖的饮用溶液。在这份报告中，我们描述了增加的交感神经活动在心脏的过度喂养的动物后，3d的蔗糖补充。这种交感神经活动的增加可能有助于与过度喂养相关的产热增强。
THE activity of the sympathetic nervous system in the rat is markedly reduced by 2 d of fasting, and this suppression is reversed by feeding1. Studies of urinary catecholamine excretion in fasting rats have corroborated these findings and in addition have shown that urinary adrenaline and noradrenaline (NA) excretion actually exceed baseline levels on the second and third days of refeeding2. Since dietary intake in these previously fasted animals was greater than baseline during the refeeding period, the possibility arose that overfeeding might be associated with increased sympathetic activity and led to the present investigation. Work by others has provided evidence that supplementation of a standard rat chow diet with sucrose-containing drinking solutions increases total caloric intake of the rat by approximately 20%3. Thus the experimental design for voluntary overfeeding in the rat is based on the addition of sucrose-containing drinking solutions to the animals' ad libitum access to rat chow and water during the experimental period. In this report we describe increased sympathetic activity in the hearts of overfed animals after 3d of sucrose supplementation. Such an increase in sympathetic activity may contribute to the enhanced thermogenesis associated with overfeeding.