Uterine and postnatal maternal effects in mice selected for differential rate of early development.
Uterine and postnatal maternal effects in mice selected for differential rate of early development.
复制标题
选择不同早期发育率的小鼠的子宫和产后母体效应。
DOI：
10.1093/genetics/153.2.905
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发表时间：
1999
期刊：
影响因子：
3.3
通讯作者：
Atchley,WR
中科院分区：
文献类型：
--
作者：
Rhees,BK;Ernst,CA;Miao,CH;Atchley,WR
通过长期的限制性指标选择，在出生后早期和后期发育过程中产生了一系列不同生长速率的小鼠品系。选育方案基于以下处理：选择E+和E系，改变出生至10 d增重，同时保持两系的后期增重不变，随机选择一个对照系。通过胚胎移植和交叉培养方法，我们将E+系、E-系和C系的产后生长分为子代遗传、子宫母系和哺乳母系。选择不同的早期生长导致子宫和护理母亲对体重的相关反应，具有显着的遗传-环境相互作用。在尾长测量中也观察到明显的子宫效应。子宫对体重的直接影响相对较小，导致发育早期的生长速度差异。护理影响很大，导致后代生长轨迹的改变，特别是在出生后早期发育。遗传与子宫的相互作用很大，并证明了产前子宫环境对后代的特异性影响。
A series of mouse lines was produced by long-term restricted index selection for divergent rate of growth during early and late postnatal development. The selection program was based on the following treatments: E+and E-lines were selected to alter birth to 10-day weight gain while holding late gain for both lines constant and a control line was established via random selection. Using embryo transfer and crossfostering methodology, we partitioned postnatal growth for E+, E-, and C lines into progeny genetic, uterine maternal, and nurse maternal components. Selection for differential early growth resulted in correlated response in uterine and nurse maternal effects on body weights, with significant genetic-by-environment interactions. Significant uterine effects were also observed in tail length measurements. Direct uterine effects on body weight were relatively small and resulted in growth rate differences early in development. Nurse effects were large, resulting in modification of progeny growth trajectory especially during early postnatal development. Genetic-by-uterine interactions were large and demonstrate progeny-specific effects of the prenatal uterine environment.