Adaptive feature detection from differential processing in parallel retinal pathways.
Adaptive feature detection from differential processing in parallel retinal pathways.
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DOI：
10.1371/journal.pcbi.1006560
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发表时间：
2018-11
影响因子：
4.3
通讯作者：
Baccus SA
中科院分区：
文献类型：
--
作者：
Ozuysal Y;Kastner DB;Baccus SA
为了在变化的环境中有效地传输信息，视网膜通过调整其增益、延迟和平均响应来适应视觉对比度。另外，时间频率选择性或带宽改变以在刺激环境有噪声时对绝对强度进行编码，并且在噪声低时对强度差进行编码。我们发现，开-关视网膜无长突细胞和神经节细胞的通路需要改变时间带宽，但不是其他自适应特性。这种显著特异的适应机制源于对比度对开启和关闭通路的不同影响。我们分析了一个只适合细胞膜电位的生物物理模型，并验证了它准确地揭示了这两个途径。我们的结论是，带宽的变化主要是从两个途径中的突触阈值的差异，而不是突触释放动力学，如以前提出的对比度适应的基础。在两条独立自适应的神经通路中，通过不同的阈值选择不同的有效码。
To transmit information efficiently in a changing environment, the retina adapts to visual contrast by adjusting its gain, latency and mean response. Additionally, the temporal frequency selectivity, or bandwidth changes to encode the absolute intensity when the stimulus environment is noisy, and intensity differences when noise is low. We show that the On pathway of On-Off retinal amacrine and ganglion cells is required to change temporal bandwidth but not other adaptive properties. This remarkably specific adaptive mechanism arises from differential effects of contrast on the On and Off pathways. We analyzed a biophysical model fit only to a cell’s membrane potential, and verified pharmacologically that it accurately revealed the two pathways. We conclude that changes in bandwidth arise mostly from differences in synaptic threshold in the two pathways, rather than synaptic release dynamics as has previously been proposed to underlie contrast adaptation. Different efficient codes are selected by different thresholds in two independently adapting neural pathways.
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影响因子：
64.8
作者：
Behnia, Rudy;Clark, Damon A.;Carter, Adam G.;Clandinin, Thomas R.;Desplan, Claude
通讯作者：
Desplan, Claude
影响因子：
5.3
作者：
Kim, KJ;Rieke, F
通讯作者：
Rieke, F
DOI：
10.1523/jneurosci.2631-11.2011
发表时间：
2011-07-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Jarsky T;Cembrowski M;Logan SM;Kath WL;Riecke H;Demb JB;Singer JH
通讯作者：
Singer JH
影响因子：
9.8
作者：
Geffen, Maria Neimark;de Vries, Saskia E J;Meister, Markus
通讯作者：
Meister, Markus
影响因子：
16.2
作者：
Baccus, SA;Meister, M
通讯作者：
Meister, M