3-Hydroxyisoflavanones from the stem bark of Dalbergia melanoxylon: Isolation, antimycobacterial evaluation and molecular docking studies
3-Hydroxyisoflavanones from the stem bark of Dalbergia melanoxylon: Isolation, antimycobacterial evaluation and molecular docking studies
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DOI：
10.1016/j.phytol.2013.08.018
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发表时间：
2013-11-01
影响因子：
1.7
通讯作者：
Yenesew, Abiy
中科院分区：
文献类型：
--
作者：
Mutai, Peggoty;Heydenreich, Matthias;Yenesew, Abiy
从黄檀树皮中分离得到两个新的3-羟基异黄酮类化合物(S)-3，4‘，5-trihydroxy-2’，7-dimethoxy-3‘-prenylisoflavanone(俗称苦参酮F7-甲醚)和(S)-3，5-二羟基-2’，7-二甲氧基-2‘，2’‘-二甲基吡喃并[5’‘，6’‘：3’，4‘]异黄酮酮(俗称苦参素-7-甲醚)和2个已知化合物(达伯金和芒柄花素)。用波谱技术对其结构进行了鉴定。新化合物Kenusanone F7-甲醚对结核分枝杆菌有一定的抗结核活性，但在10µg/ml时对恶性疟原虫无活性。对接研究表明，新化合物Kenusanone F7-甲醚和苦参素-7-甲醚对结核分枝杆菌药物靶标INHA具有较高的亲和力。(C)2013年欧洲植物化学学会。爱思唯尔出版，版权所有。
Two new 3-hydroxyisoflavanones, (S)-3,4',5-trihydroxy-2',7-dimethoxy-3'-prenylisoflavanone (trivial name kenusanone F 7-methyl ether) and (S)-3,5-dihydroxy-2',7-dimethoxy-2 '',2 ''-dimethylpyrano[5 '',6 '':3',4']isoflavanone (trivial name sophoronol-7-methyl ether) along with two known compounds (dalbergin and formononetin) were isolated from the stem bark of Dalbergia melanoxylon. The structures were elucidated using spectroscopic techniques. Kenusanone F 7-methyl ether showed activity against Mycobacterium tuberculosis, whereas both of the new compounds were inactive against the malaria parasite Plasmodium falciparum at 10 mu g/ml. Docking studies showed that the new compounds kenusanone F 7-methyl ether and sophoronol-7-methyl ether have high affinity for the M. tuberculosis drug target INHA. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.