[Biological perspectives].
[Biological perspectives].
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DOI：
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发表时间：
1998
影响因子：
0.6
通讯作者：
J. Pujol;P. Demoly;X. Quantin;J. Simony;É. Parrat;M. Lehmann;J. Daurès;G. Jolimoy;J. Grenier;B. Pau;P. Godard
中科院分区：
文献类型：
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作者：
J. Pujol;P. Demoly;X. Quantin;J. Simony;É. Parrat;M. Lehmann;J. Daurès;G. Jolimoy;J. Grenier;B. Pau;P. Godard
非小细胞支气管癌的肿瘤生物学整合了肿瘤进展和转移性疾病扩散现象的最新进展和动态模式。第二阶段和第三阶段之间没有已知的生物破坏的飞跃。后者是由解剖学标准定义的，是这些癌症自然史连续体的过渡。肿瘤进展的动力是基因型不稳定和表型多样化。转移性微观疾病是III期非小细胞支气管癌治疗失败的首要原因。在生存的预后因素中，重点放在 p53 表达的改变、不同类型的非整倍性、细胞粘附分子表达的异常以及最后的肿瘤向转移表型的多样化。
The tumour biology of non-small cell bronchial cancer integrates recent developments and a dynamic schema of the phenomena of tumour progression and diffusion of the metastatic disease. There is no leap of known biological disruption between Stage II and Stage III. The latter is defined by anatomical criteria and is a transition in the continuum of the natural history of these cancers. The moto for the tumour progression is the genotypic instability and phenotypic diversification. Metastatic microscopic disease constitutes the first cause of failure in the treatment of Stage III non-small cell bronchial cancer. Among prognostic factors for survival emphasis is placed on the alterations of p53 expression, different types of aneuploidy, anomalies of the expression of cellular adhesion molecules and finally, tumour diversification towards a metastatic phenotype.