Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium
Influence of the novel inotropic agent levosimendan on isometric tension and calcium cycling in failing human myocardium
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DOI：
10.1161/01.cir.98.20.2141
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发表时间：
1998-11-17
期刊：
影响因子：
37.8
通讯作者：
Just, H
中科院分区：
文献类型：
--
作者：
Hasenfuss, G;Pieske, B;Just, H
背景-左西孟旦被证明可以通过一种新的机制增加钙敏感性，并抑制动物心肌中磷酸二酯酶 III 的活性。方法和结果-我们研究了左西孟旦对患有 2 期失败扩张型或缺血性心肌病 (n = 27) 的人类心脏肌肉条中的等长收缩和钙瞬变（水母发光蛋白法）的影响。将数据与磷酸二酯酶抑制剂米力农的效果进行比较（n=9）。当左西孟旦浓度为 0.8+/-0.3 μmol/L 时，抽搐张力的平均最大增加为 47+/-14%（范围为 6% 至 150%）（P
Background-Levosimendan was shown to increase calcium sensitivity by a novel mechanism and to inhibit phosphodiesterase III activity in animal myocardium.Methods and Results-We investigated the influence of levosimendan on isometric contractions and calcium transients (aequorin method) in muscle strips from human hearts with and-stage failing dilated or ischemic cardiomyopathy (n=27). Data were compared with the effects of the phosphodiesterase inhibitor milrinone (n=9). The average maximum increase in twitch tension was 47+/-14% (range, 6% to 150%) at a levosimendan concentration of 0.8+/-0.3 mu mol/L (P