Fast-to-slow shift of muscle fiber-type composition by dietary apple polyphenols in rats: Impact of the low-dose supplementation
Fast-to-slow shift of muscle fiber-type composition by dietary apple polyphenols in rats: Impact of the low-dose supplementation
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DOI：
10.1111/asj.12655
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发表时间：
2017-03-01
影响因子：
2
通讯作者：
Tatsumi, Ryuichi
中科院分区：
文献类型：
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作者：
Mizunoya, Wataru;Okamoto, Shinpei;Tatsumi, Ryuichi
我们先前的研究表明，在饮食中摄入5%(w/w)的苹果多酚(APP)8周可以提高幼年-成年大鼠的肌肉耐力。为了确定APP对这一效应的饮食贡献的下限，本实验设计了12周龄雄性SD大鼠的低剂量补充(在AIN-93G饲料中添加0.5%APP 8周)。结果表明，0.5%的APP显著上调了后肢肌肉中较慢的肌球蛋白重链(MyHC)亚型比率(IIx和IIa)和肌红蛋白的表达(P
Our previous studies demonstrated that an 8-week intake of 5% (w/w) apple polyphenol (APP) in the diet improves muscle endurance of young-adult rats. In order to identify a lower limit of the dietary contribution of APP to the effect, the experiments were designed for lower-dose supplementation (8-week feeding of 0.5% APP in AIN-93G diet) to 12-week-old male Sprague-Dawley rats. Results clearly showed that the 0.5% APP diet significantly up-regulates slower myosin-heavy-chain (MyHC) isoform ratios (IIx and IIa relative to total MyHC) and myoglobin expression in lower hind-limb muscles examined (P