Dopamine D1 receptor antagonist inhibits swallowing reflex in guinea pigs
Dopamine D1 receptor antagonist inhibits swallowing reflex in guinea pigs
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DOI：
10.1152/ajpregu.1998.274.1.r76
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发表时间：
1998-01-01
影响因子：
2.8
通讯作者：
Sasaki, H
中科院分区：
文献类型：
--
作者：
Jia, YX;Sekizawa, K;Sasaki, H
为了确定多巴胺D-1受体拮抗剂是否会损害吞咽反射并减少外周器官中的P物质（SP），在用Sch-23390预处理的麻醉豚鼠中，通过导管向咽部注射三种不同体积（0.2、0.4和0.6 ml）的蒸馏水，检查吞咽反射的吞咽次数。每12 h用皮下Sch-23390（200 μ g/kg）或Sch-23390溶媒预处理动物，持续7天。通过颏下肌电活动和视觉观察特征性喉运动来计数吞咽次数。注射蒸馏水导致未接受Sch-23390治疗的动物吞咽次数呈体积依赖性增加。Sch-23390显著降低了所有体积蒸馏水引起的吞咽次数，外源性SP增加了吞咽次数。FK-888（10（-5）M，1 ml）是一种NK 1受体的特异性抑制剂，与Sch-23390相比，其减少吞咽次数的程度更大。与对照组相比，Sch-23390显著降低喉和咽粘膜中的SP含量。这些结果表明，多巴胺D-1受体的抑制可能会损害吞咽反射和减少SP含量在外周器官。
To determine whether dopamine D-1 receptor antagonist impairs the swallowing reflex and reduces substance P (SP) in the peripheral organs, the swallowing reflex in terms of the number of swallows elicited by injections of three different volumes (0.2, 0.4, and 0.6 ml) of distilled water into the pharynx through a catheter was examined in anesthetized guinea pigs pretreated with Sch-23390. Animals were pretreated with either subcutaneous Sch-23390 (200 mu g/kg) or a vehicle of Sch-23390 every 12 h for 7 days. The number of swallows was counted by submental electromyographic activity and visual observation of characteristic laryngeal movement. Injections of distilled water caused a volume-dependent increase in the number of swallows in animals without Sch-23390 treatment. Sch-23390 significantly decreased and exogenously administered SP increased the number of swallows elicited by all volumes of distilled water. FK-888 (10(-5) M, 1 ml), a specific inhibitor of the NK1 receptor, reduced the number of swallows to a greater degree than Sch-23390. Sch-23390 significantly reduced SP content in the laryngeal and pharyngeal mucosa compared with control. These results suggest that inhibition of the dopamine D-1 receptor may impair the swallowing reflex and reduce SP content in the peripheral organs.