Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review.
Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review.
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兽医患者的临床前动物模型和自发性肿瘤的组织疗法消融：综述。
DOI：
10.1109/tuffc.2021.3110083
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发表时间：
2022-01
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抗击癌症迫切需要新的治疗策略。在过去的十年里，几种肿瘤消融策略以单独或联合疗法的形式出现。组织电切是第一种完全非侵入性、非热疗和非电离的肿瘤消融方法。组织检查可以产生持续和快速的消融，甚至在关键结构附近也是如此。其他好处包括实时图像引导、高精度，以及能够治疗任何预定大小和形状的肿瘤。不幸的是，缺乏临床和生理上相关的临床前癌症模型往往是所有局部肿瘤消融策略的一个重要限制。大多数测试组织摩擦学用于癌症治疗的研究都集中在小动物模型上，这些模型在推动这一领域向前发展方面发挥了关键作用，而且将继续对提供机械洞察力至关重要。虽然这些小动物模型具有显著的翻译价值，但在规模和解剖学相关性方面存在重大限制。为了解决这些局限性，出现了一系列不同的大型动物模型和兽医患者的自发肿瘤研究，以补充现有的啮齿动物模型。这些模型和兽医患者很好地为开发和测试组织摩擦设备和技术提供了现实的途径，这些设备和技术是为未来用于人类患者而设计的。在这里，我们回顾了临床前组织学研究中使用的动物模型，并使用一系列原始病例报告比较了这些模型中的组织学消融治疗，涉及广泛的临床前动物模型和兽医患者的自发性肿瘤。
New therapeutic strategies are direly needed in the fight against cancer. Over the last decade, several tumor ablation strategies have emerged as stand-alone or combination therapies. Histotripsy is the first completely non-invasive, non-thermal, and non-ionizing tumor ablation method. Histotripsy can produce consistent and rapid ablations, even near critical structures. Additional benefits include real-time image-guidance, high precision, and the ability to treat tumors of any predetermined size and shape. Unfortunately, the lack of clinically and physiologically relevant pre-clinical cancer models is often a significant limitation with all focal tumor ablation strategies. The majority of studies testing histotripsy for cancer treatment have focused on small animal models, which have been critical in moving this field forward and will continue to be essential for providing mechanistic insight. While these small animal models have notable translational value, there are significant limitations in terms of scale and anatomical relevance. To address these limitations, a diverse range of large animal models and spontaneous tumor studies in veterinary patients have emerged to complement existing rodent models. These models and veterinary patients are excellent at providing realistic avenues for developing and testing histotripsy devices and techniques designed for future use in human patients. Here, we provide a review of animal models used in preclinical histotripsy studies and compare histotripsy ablation in these models using a series of original case reports across a broad spectrum of preclinical animal models and spontaneous tumors in veterinary patients.