Human rhinovirus infection during naturally occurring COPD exacerbations
Human rhinovirus infection during naturally occurring COPD exacerbations
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DOI：
10.1183/09031936.00223113
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发表时间：
2014-07-01
影响因子：
24.3
通讯作者：
Wedzicha, Jadwiga A.
中科院分区：
文献类型：
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作者：
George, Siobhan N.;Garcha, Davinder S.;Wedzicha, Jadwiga A.
人鼻病毒 (HRV) 感染是慢性阻塞性肺疾病 (COPD) 恶化的重要触发因素，但其在确定恶化频率表型或自然发生的恶化中 HRV 感染时程的作用尚不清楚。通过实时定量 PCR 分析了 77 名患者的痰样本中的 HRV（388 个样本）以及肺炎链球菌、流感嗜血杆菌和卡他莫拉菌（89 个样本）。患
Human rhinovirus (HRV) infection is an important trigger of exacerbations of chronic obstructive pulmonary disease (COPD) but its role in determining exacerbation frequency phenotype or the time-course of HRV infection in naturally occurring exacerbations is unknown.Sputum samples from 77 patients were analysed by real-time quantitative PCR for both HRV (388 samples), and Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis (89 samples). Patients recorded worsening of respiratory symptoms on daily diary cards, from which exacerbations were identified.HRV prevalence and load at exacerbation presentation were significantly higher than in the stable state (prevalence 53.3% versus 17.2%, respectively; p