Genetic linkage studies map the multiple endocrine neoplasia type 2 loci to a small interval on chromosome 10q11.2.
Genetic linkage studies map the multiple endocrine neoplasia type 2 loci to a small interval on chromosome 10q11.2.
复制标题
遗传连锁研究将多个内分泌肿瘤 2 型基因座定位到染色体 10q11.2 上的一个小区间。
DOI：
10.1093/hmg/2.3.241
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发表时间：
1993
影响因子：
3.5
通讯作者：
Mulligan,LM
中科院分区：
文献类型：
--
作者：
Gardner,E;Papi,L;Easton,DF;Cummings,T;Jackson,CE;Kaplan,M;Love,DR;Mole,SE;Moore,JK;Mulligan,LM
We have carried out genetic linkage analysis using fifteen polymorphic loci in the pericentromeric region of chromosome 10 in families with the inherited cancer syndromes multiple endocrine neoplasia (MEN) type 2A or 2B. A highly polymorphic microsatellite from the locusD10S141in q11.2 was found to be recombinant with respect to the disease locus in two individuals and defines a new proximal flanking marker for bothMEN2Aand 2B. An additional recombination provides evidence that the locusD10S94, also in q11.2, is the closest distal flanking marker forMEN2A. This localises theMEN2Agene to a small region of 10q11.2 flanked by the lociD10S141andD10S94, which are separated by a sex-averaged genetic distance of 0.55 cM. TheMEN2Bgene maps to a larger region, flanked byD10S141andRBP3.
