Metformin protects against cardiac and renal damage in diabetic cardiac arrest patients.
Metformin protects against cardiac and renal damage in diabetic cardiac arrest patients.
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DOI：
10.1016/j.resuscitation.2022.03.017
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发表时间：
2022-05
期刊：
影响因子：
6.5
通讯作者：
Elmer, Jonathan
中科院分区：
文献类型：
--
作者：
Rutledge, Cody A.;Kaufman, Brett A.;Dezfulian, Cameron;Elmer, Jonathan
Metformin is a first-line diabetic therapy that improves survival in a wide number of ischemic pathologies. We tested the association of metformin with markers of cardiac and renal injury in diabetic post-arrest patients. We performed a retrospective analysis of clinical outcomes in diabetic cardiac arrest patients with and without metformin therapy at a single academic medical center. We used generalized linear models to test the independent association of metformin, insulin, and other hypoglycemic agents with peak 24-hour serum creatinine and peak 24-hour serum troponin. Metformin prescription at the time of SCA was independently associated with lower 24-hour peak serum troponin and lower 24-hour peak serum creatinine when compared to non-metformin patients. Metformin pretreatment may offer cardiac and renal protection for diabetic patients during sudden cardiac arrest.
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