Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals.
Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals.
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DOI：
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发表时间：
2000-12
期刊：
影响因子：
3.4
通讯作者：
Zoeller Rt;K. Crofton
中科院分区：
文献类型：
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作者：
Zoeller Rt;K. Crofton
众所周知，甲状腺激素在大脑发育中起着至关重要的作用。因此，干扰甲状腺功能或甲状腺激素作用的环境因素可能通过干扰发育中的大脑中甲状腺激素的作用而对大脑发育产生有害影响。这篇综述的目的是从广义上确定我们对甲状腺激素在大脑发育中的作用的认识差距，将这些差距与甲状腺功能障碍的信息联系起来，并简要回顾我们最近与这些问题相关的研究。首先简要回顾了甲状腺系统的内分泌学，重点介绍了控制甲状腺激素循环水平的神经内分泌和甲状腺外机制。第二部分回顾的证据，甲状腺激素是重要的胎儿，以及新生儿，大脑发育。我们将在第三部分回顾甲状腺激素的作用机制，并将这些信息与甲状腺激素对大脑发育的作用机制的信息简单地联系起来。在最后一节中，我们回顾了甲状腺紊乱的内分泌学，重点是甲状腺激素作用的紊乱。
Thyroid hormone is well-known to play essential roles in brain development. Therefore, environmental factors that interfere with thyroid function or thyroid hormone action may produce deleterious effects on brain development by interfering with thyroid hormone action in the developing brain. The purpose of this review is to identify in broad terms the gaps in our knowledge of thyroid hormone action in brain development, to relate these gaps to present information on thyroid disruption, and to review briefly our recent research that is germane to these issues. The endocrinology of the thyroid system is first reviewed briefly with an emphasis on the neuroendocrine and extrathyroidal mechanisms controlling circulating levels of thyroid hormones. The second section reviews the evidence that thyroid hormone is important for fetal, as well as neonatal, brain development. We review the mechanism of thyroid hormone action in the third section and briefly relate this information to information about the mechanism of thyroid hormone action on brain development. In the final section, we review the endocrinology of thyroid disruption with an emphasis on disruption of thyroid hormone action.