Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasms.
Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasms.
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Beta-6 整合素、腱蛋白-C 和 MMP-1 在唾液腺肿瘤中的表达。
DOI：
10.1016/j.oraloncology.2004.08.002
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Schmidt,BrianL
中科院分区：
文献类型：
--
作者：
Westernoff,TrentH;Jordan,RichardCK;Regezi,JosephA;Ramos,DanielM;Schmidt,BrianL
β-6 Integrin, tenascin-C, and MMP-1 (matrix metalloproteinase-1) are invasion-related proteins that are frequently overexpressed in many human malignancies. The objective of this study was to determine whether there is overexpression of these molecules in three types of salivary neoplasms showing markedly different behavior. A total of 55 formalin-fixed, paraffin-embedded archived specimens comprising 19 adenoid cystic carcinomas (ACC), 18 polymorphous low-grade adenocarcinomas (PLGA) and 18 pleomorphic adenomas (PA) were utilized in this study. A standard immunohistochemical technique was used to determine the expression levels of β-6 integrin, tenascin-C, and matrix metalloproteinase-1 (MMP-1) proteins. Sections were assessed semiquantitatively, and tumors were divided into two groups, low-expressors (0–1+) and high-expressors (2–3+) for statistical analysis. Staining was graded as 0 (<1% positive tumor cells), 1+ (<25% positive tumor cells), 2+ (25–50% positive tumor cells), and 3+ (>50% positive cells). The results showed that the malignant tumors were higher expressors of β-6 than the benign tumors. ACCs showed significantly higher expression of β-6 than PAs (p=0.04). No significant difference was observed between ACCs and PLGAs. β-6 expression was rarely seen in normal salivary gland epithelium and was occasionally present in mucosa overlying the tumors. PAs were high-expressors of tenascin-C with a significant difference relative to ACCs (p=0.03). A majority of tumors in all three tumor types showed high expression of MMP1 with expression significantly greater in the PAs compared to ACCs (p=0.008). We conclude that ACCs and PLGAs express β-6, tenascin-C, and MMP-1, but that their expression patterns are not significantly different. β-6 appears to be more closely associated with the malignant tumors, and MMP-1 more closely associated with the benign tumors. We believe that β-6, tenascin-C, and MMP-1 proteins are part of the molecular repertoire used by salivary tumors for malignant invasion and benign tumor expansion.
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