ISOLATION OF 2 TOXIC HEPTAPEPTIDE MICROCYSTINS FROM AN AXENIC STRAIN OF MICROCYSTIS-AERUGINOSA, K-139
ISOLATION OF 2 TOXIC HEPTAPEPTIDE MICROCYSTINS FROM AN AXENIC STRAIN OF MICROCYSTIS-AERUGINOSA, K-139
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DOI：
10.1016/0041-0101(91)90022-j
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发表时间：
1991-01-01
期刊：
影响因子：
2.8
通讯作者：
NAKANO, M
中科院分区：
文献类型：
--
作者：
HARADA, K;OGAWA, K;NAKANO, M
从一株无菌铜绿微囊藻K-139中分离到两个有毒的七肽类化合物。主要采用非破坏性核磁共振方法，确定了主要毒素的结构为7-脱甲基微囊藻毒素LR，该毒素缺少脱氢丙氨酸部分的N-甲基。次要毒素为3，7-二脱甲基微囊藻毒素LR。比较了7-去甲基微囊藻毒素LR和3-去甲基微囊藻毒素LR的层析和核磁共振分析结果。
Two toxic heptapeptides were isolated from an axenic Microcystis aeruginosa strain, K-139. Using mainly a non-destructive NMR method, we determined the structure of the major toxin to be 7-desmethylmicrocystin LR which lacks an N-methyl group of the dehydroalanine moiety of microcystin LR. The minor toxin was deduced to be 3,7-didesmethylmicrocystin LR. The chromatographic and NMR analyses of 7-desmethylmicrocystin LR were compared with those of 3-desmethylmicrocystin LR.